Anti-NMDA NR2B Subunit (Tyr1472) Antibody


Our Anti-NMDA NR2B Subunit (Tyr1472) rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is produced in-house. It detects mouse and rat NMDA NR2B Subunit (Tyr1472) and is antigen affinity purified from pooled serum. It is great for use in WB.

Primary Antibody
Mouse, Rat
Bovine, Canine, Chicken, Human, Non-Human Primate, Zebrafish
WB
Rabbit
Antigen Affinity Purified from Pooled Serum
GRIN2B
180 kDa

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Anti-NMDA NR2B Subunit (Tyr1472) Antibody
SKU: p1516-1472

Volume: 100 µL
Price:
Sale price$390


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Product Specific References for Applications and Species

Immunocytochemistry: Rat
PMID Dilution Publication
32651756 1:100 Akkuratov, E.E., et al. 2020. Ouabain Modulates the Functional Interaction Between Na, K-ATPase and NMDA Receptor. Molecular Neurobiology, pp.1-13.
Western Blot: Mouse
PMID Dilution Publication
31135041 1:1000 Dedek, A., et al. 2019. Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing. Brain, 142(6), pp.1535-1546.
Western Blot: Mouse
PMID Dilution Publication
34044147 1:1000 Zhang, L., et al. 2021. Tyrosine phosphatase PTP1B impairs presynaptic NMDA receptor-mediated plasticity in a mouse model of Alzheimer's disease. Neurobiology of Disease, 156, p.105402.
31543505 1:1000 Ajit, D., et al. 2020. A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylation. Journal of Biological Chemistry, 294(45), pp.16698-16711.
30518596 1:1000 Salazar, S.V., et al. 2019. Alzheimer's disease risk factor Pyk2 mediates amyloid-β-induced synaptic dysfunction and loss. Journal of Neuroscience, 39(4), pp.758-772.
31452242 1:1000 Liu, G., et al. 2019. Loss of tau and Fyn reduces compensatory effects of MAP2 for tau and reveals a Fyn‐independent effect of tau on calcium. Journal of neuroscience research. Aug 26.
30551522 not listed Zhang, X., et al. 2019. Effects of 5-Aza on p-Y1472 NR2B related to learning and memory in the mouse hippocampus. Biomedicine & Pharmacotherapy, 109, pp.701-707.
27335408 not listed Xiao, X., et al. 2016. Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice. The Journal of Neuroscience, 36(25), 6778-6791.
27094400 1:1000 Zamzow, D.R., et al. 2016. Higher levels of phosphorylated Y1472 on GluN2B subunits in the frontal cortex of aged mice are associated with good spatial reference memory, but not cognitive flexibility. AGE, 38(3), 1-17.
22544749 1:1000 Xu, J., et al. 2012. Striatal-enriched protein-tyrosine phosphatase (STEP) regulates Pyk2 kinase activity. J Biol Chem. Jun 15;287(25):20942-56.
22523092 1:500 Gladding, C.M., et al. 2012. Calpain and Striatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington’s disease mouse model. Hum Mol Genet. Sep 1;21(17):3739-52.
21464302 1:1000 Hinklin, T.R., et al. 2011. Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase. PNAS, Apr 2011; 108: 6650 - 6655.
20427654 1:1000 Kurup, P., et al. 2010. Aβ-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61. Journal of Neuroscience, 30(17), pp.5948-5957.
Western blot: Rat
PMID Dilution Publication
34653560 1:1500 Su, L., et al. 2021. . P2Y1 purinergic receptor inhibition attenuated remifentanil-induced postoperative hyperalgesia via decreasing NMDA receptor phosphorylation in dorsal root ganglion. Brain Research Bulletin, 177, pp.352-362.
34166321 1:1000 Su, L., et al. 2021. . P2Y1 Purinergic Receptor Contributes to Remifentanil-Induced Cold Hyperalgesia via Transient Receptor Potential Melastatin 8–Dependent Regulation of N-methyl-d-aspartate Receptor Phosphorylation in Dorsal Root Ganglion. Anesthesia & Analgesia, 133(3), pp.794-810.
33257326 not listed Higginbotham, J.A., et al. 2021. . CB1 receptor signaling modulates amygdalar plasticity during context-cocaine memory reconsolidation to promote subsequent cocaine seeking. Journal of Neuroscience, 41(4), pp.613-629.
32437889 1:500 Zhu, D., et al. 2020. . Angiotensin (1-7) through modulation of the NMDAR–nNOS–NO pathway and serotonergic metabolism exerts an anxiolytic-like effect in rats. Behavioral Brain Research, 390, p.112671.
27127657 not listed Jang, S.S., et al. 2016. Seizure-Induced Regulations of Amyloid-β, STEP61, and STEP61 Substrates Involved in Hippocampal Synaptic Plasticity. Neural plasticity, 2016.
26391783 not listed Jang, S.S., et al. 2015. Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity. Molecular brain, 8.
26277342 not listed Mao, L.M., et al. 2015. Dopaminergic and cholinergic regulation of Fyn tyrosine kinase phosphorylation in the rat striatum in vivo. Neuropharmacology, 99, 491-499.
24611998 1:1000 Chen, W., et al. 2014. BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. European Journal of Neuroscience, 39(9), 1439-1454.
21464302 1:1000 Hinklin, T.R., et al. 2011. Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase. PNAS, Apr 2011; 108: 6650 - 6655.
21215796 1:1000 Castillo, C., et al. 2011. The N-methyl-D-aspartate-evoked cytoplasmic calcium increase in adult rat dorsal root ganglion neuronal somata was potentiated by substance P pretreatment in a protein kinase C-dependent manner. Neuroscience, 177, pp.308-320.
20427654 1:1000 Kurup, P., et al. 2010. Aβ-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61. Journal of Neuroscience, 30(17), pp.5948-5957.
19625523 1:1000 Xu, J., et al. 2009. Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP. Journal of Neuroscience, 29(29), pp.9330-9343.
12536146 1:1000 Alvested, R.M., et al. 2003. Tyrosine dephosphorylation and ethanol inhibition of N-methyl-D-aspartate receptor function. Journal of Biological Chemistry, 278(13), pp.11020-11025.

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