Anti-Navbeta3 Na+ Channel Antibody (N396/29)

Name: Anti-Navbeta3 Na+ Channel Antibody
Brand: NeuroMab
SKU: 75-391
Price: 319.0 USD
Availability: InStock

Our Anti-Navbeta3 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N396/29. It detects mouse and rat Navbeta3 Na+ channel, and is purified by Protein A chromatography. It is great for use in ICC, WB.

Extracts of COS cells transiently transfected with GFP-tagged Navbeta1, V5/His-tagged Navbeta2, V5/His-tagged Navbeta3, GFP-tagged Navbeta4 or untagged Kv2.1 plasmid and probed with mouse anti-V5 (center), N396/29 (left) and N52A/42 (right) TC supes.

Transfected cell immunoblot

Species Reactivity

Mouse, Rat

Applications

ICC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-391

Volume: 100 µL

Variant

Price:

$319

Quantity:

Product Details

Target

Navbeta3 Na+ channel

Target Description

Sodium channel subunit beta-3 or Navbeta3 Na+ channel is encoded by SCN3B. Voltage gated sodium channels are made up of an alpha (pore forming) subunit and 1 or 2 beta subunits. Navß3 is a transmembrane protein and acts as a regulatory subunit in excitable membranes and modulates the kinetics of channel. Nabß3 is expressed in many tissues, including the central and peripheral nervous system, heart and pancreatic endocrine cells. Diseases associated with SCN3A include forms of Epilepsy and Encephalopathy.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N396/29

Isotype

IgG2b

Applications

ICC, WB

Host Species

Mouse

Gene Name

Scn3b

Molecular Weight

40 kDa

Antigen

Fusion protein amino acids 1-215 (full-length) of rat Navbeta3 (accession number Q9JK00) produced recombinantly in E. Coli

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2491090

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with Navbeta1, Navbeta2 or Navbeta4

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Sodium channel subunit beta-3

UniProt Details

UniProt (Human): Q9NY72
UniProt (Immunogen Species): Q9JK00

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Anti-Navbeta3 Na+ Channel Antibody (N396/29)

SKU: 75-391

Product Details

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