Sodium channel subunit beta-3 or Navbeta3 Na+ channel is encoded by SCN3B. Voltage gated sodium channels are made up of an alpha (pore forming) subunit and 1 or 2 beta subunits. Navß3 is a transmembrane protein and acts as a regulatory subunit in excitable membranes and modulates the kinetics of channel. Nabß3 is expressed in many tissues, including the central and peripheral nervous system, heart and pancreatic endocrine cells. Diseases associated with SCN3A include forms of Epilepsy and Encephalopathy.
Fusion protein amino acids 1-215 (full-length) of rat Navbeta3 (also known as Sodium channel subunit beta-3, Scn3b and KIAA1158, accession number Q9JK00); Mouse: 99% identity (214/215 amino acids identical); Human: 98% identity (211/215 amino acids identical); 50% identity with Navbeta1, Navbeta2 or Navbeta4
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