Anti-Nav1.8 Na+ Channel Antibody (N134/12)

Name: Anti-Nav1.8 Na+ Channel Antibody
Brand: NeuroMab
SKU: 75-166
Price: 345.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

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Clonality

Monoclonal

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Scn10a Sns

Molecular Weight

220 kDa

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Stable/transfected cell immunoblot: extracts of HEK cells stably expressing Nav1.7 and COS cells transiently transfected with GFP-tagged Nav1.8 or untagged Kv2.1 plasmids and probed with N134/12 TC supe.

Immunofluorescence staining of cultured dorsal root ganglia neurons from Nav1.8 WT and KO mice with N134/12 TC supe. Image courtesy of Dr. Joel Black, Dr. Sulayman Dib-Hajj and Dr. Steve Waxman, Yale University.

Immunofluorescence staining of rat dorsal root ganglia cryosections. N134/12 TC supe = green, neurofilament = red. Image courtesy of Dr. Joel Black, Dr. Sulayman Dib-Hajj and Dr. Steve Waxman, Yale University.

Stable/transfected cell immunoblot: extracts of HEK cells stably expressing Nav1.7 and COS cells transiently transfected with GFP-tagged Nav1.8 or untagged Kv2.1 plasmids and probed with N134/12 TC supe.

Product Details

Target

Nav1.8 Na+ channel

Target Description

NAV1.8 is a member of the voltage-gated sodium channel family, which function in producing and propagating action potentials. Sodium channels are composed of a large alpha subunit that may be associated with one or more smaller beta subunits. Nav 1.8 is an integral membrane glycoprotein that is responsible for the initial rising phase of action in most excitable cells. Nav 1.8 is expressed in neurons in the dorsal root ganglion (DRG). and appears to have a role in pain pathways.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N134/12

Isotype

IgG2a

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Scn10a Sns

Molecular Weight

220 kDa

Antigen

Fusion protein amino acids 1724-1956 (cytoplasmic C-terminus) of rat Nav1.8(also known as Sodium channel protein type 10 or X subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.8, Peripheral nerve sodium channel 3, PN3 or Sensory neuron sodium channel, accession number Q62968); Mouse: 93% identity (220/235 amino acids identical); Human: 85% identity (200/234 amino acids identical); Greater than 50% identity with Nav1.7 and Nav1.5

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2183861

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not react with Nav1.7

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (Sensory neuron sodium channel) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8)

UniProt Details

UniProt (Human): Q9Y5Y9
UniProt (Immunogen Species): Q62968

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Anti-Nav1.8 Na+ Channel Antibody (N134/12)

Anti-Nav1.8 Na+ Channel Antibody
SKU: 75-166

Product Details

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Anti-Nav1.8 Na+ Channel Antibody (N134/12)

Anti-Nav1.8 Na+ Channel Antibody SKU: 75-166

Product Details

Anti-Nav1.8 Na+ Channel Antibody
SKU: 75-166