Anti-mGluR1/5 (Group I) Glutamate Receptor Antibody (N75/3)

Name: Anti-mGluR1/5 (Group I) Glutamate Receptor Antibody
Brand: NeuroMab
SKU: 75-115
Price: 285.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Grm5 Gprc1e Mglur5

Molecular Weight

130 kDa(both mGluR1 and mGluR5)

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Adult rat hippocampus immunohistochemistry.

Adult rat brain membrane immunoblot.

Product Details

Target

mGluR1/5 (Group I) glutamate receptor

Target Description

The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus (Francesconi et al., 2004).

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N75/3

Isotype

IgG2a

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Grm5 Gprc1e Mglur5

Molecular Weight

130 kDa(both mGluR1 and mGluR5)

Antigen

Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b (also known as metabotropic glutamate receptor 5, accession number P31424); Mouse: 96% identity (368/388 amino acids identical); Human: 87% identity (339/388 amino acids identical); Less than 35% identity with mGluR1

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_10672260

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Conjugate

Unconjugated

Specificity

Recognizes mGluR1 and mGluR5

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Metabotropic glutamate receptor 5 (mGluR5)

UniProt Details

UniProt (Human): P41594
UniProt (Immunogen Species): P31424

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Anti-mGluR1/5 (Group I) Glutamate Receptor Antibody (N75/3)

Anti-mGluR1/5 (Group I) Glutamate Receptor Antibody
SKU: 75-115

Product Details

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Anti-mGluR1/5 (Group I) Glutamate Receptor Antibody (N75/3)

Anti-mGluR1/5 (Group I) Glutamate Receptor Antibody SKU: 75-115

Product Details

Anti-mGluR1/5 (Group I) Glutamate Receptor Antibody
SKU: 75-115