Anti-Mad3 (Human) Antibody (N129/15)

Name: Anti-Mad3 (Human) Antibody
Brand: NeuroMab
SKU: 75-250
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

4 Citations

Product Type

Primary Antibody

Species Reactivity

Human

Clone

N129/15

Applications

ICC, WB

Host Species

Mouse

Format

Purified

Gene Name

MXD3 BHLHC13 MAD3

Molecular Weight

25 kDa

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Transfected cell immunoblot: extracts of COS cells transiently transfected with HA-tagged mouse and human Mad3 (mMad3 and hMad3, respectively) or untagged Kv2.1 plasmid and probed with N129/15 (left) and K89/41 (right) TC supes.

Volume: 100 µL

Variant

Price:

$308

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Product Details

Target

Mad3 (human)

Target Description

MAX Dimerization Protein 3 is encoded by the gene MXD3. MXD3 is a member of the Myc superfamily. MXD3 is a transcriptional repressor which forms a heterodimer with the cofactor MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXD3 is expressed in lung and blood. Diseases associated with MXD3 include Perianal Hematoma and Bartholin's Duct Cyst.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N129/15

Isotype

IgG2b

Applications

ICC, WB

Host Species

Mouse

Gene Name

MXD3 BHLHC13 MAD3

Molecular Weight

25 kDa

Antigen

Fusion protein amino acids 116-206 (C-terminus) of human Mad3 (also known as Max-interacting transcriptional repressor, Max-associated protein 3, MAX dimerization protein 3, Myx and Mxd3, accession number Q9BW11); Mouse: 82% identity (75/91 amino acids identical); Rat: 78% identity (71/91 amino acids identical); ~50% identity with Mxi1

Species Reactivity

Human

Antibody Registry ID

AB_11001559

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with Mxi1

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Max dimerization protein 3 (Max dimerizer 3) (Class C basic helix-loop-helix protein 13) (bHLHc13) (Max-associated protein 3) (Max-interacting transcriptional repressor MAD3) (Myx)

UniProt Details

UniProt (Human): Q9BW11
UniProt (Immunogen Species): Q9BW11

Barisone GA, Satake N, Lewis C, Duong C, Chen C, Lam KS, Nolta J, Dίaz E. (2015), 'Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells..' Blood Cells Mol Dis.. 10.1016/j.bcmd.2014.12.002.
Satake N, Duong C, Chen C, Barisone GA, Diaz E, Tuscano J, Rocke DM, Nolta J, Nitin N. (2014), 'Targeted therapy with MXD3 siRNA, anti-CD22 antibody and nanoparticles for precursor B-cell acute lymphoblastic leukaemia..' Br J Haematol.. 10.1111/bjh.13066.
Ngo T, Barisone GA, Lam KS, Dίaz E. (2014), 'MXD3 regulation of DAOY cell proliferation dictated by time course of activation..' BMC Cell Biol.. 10.1186/1471-2121-15-30.
Carneiro K, Donnet C, Rejtar T, Karger BL, Barisone GA, Díaz E, Kortagere S, Lemire JM, Levin M. (2011), 'Histone deacetylase activity is necessary for left-right patterning during vertebrate development..' BMC Dev Biol.. 10.1186/1471-213X-11-29.

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Anti-Mad3 (Human) Antibody (N129/15)

Anti-Mad3 (Human) Antibody
SKU: 75-250

Bulk Order Anti-Mad3 (Human) Antibody

Product Details

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Anti-Mad3 (Human) Antibody (N129/15)

Anti-Mad3 (Human) Antibody SKU: 75-250

Bulk Order Anti-Mad3 (Human) Antibody

Product Details

Anti-Mad3 (Human) Antibody
SKU: 75-250