Products: Primary Antibodies

Anti-Tyrosine Hydroxylase Antibody (LNC1)

from Antibodies Incorporated

PRODUCT OPTIONS

★ Trial Size Available ★

Brand	Catalog #	Option	Volume	Concentration	Price
Brand	Catalog # 76-700-100	Option Ascites Fluid	Volume 100 µL	Concentration Ascites fluid	Price $335.00
Brand	Catalog # 76-700-020	Option Ascites Fluid-Trial size	Volume 20 µL	Concentration Ascites fluid	Price $115.00
Brand	Catalog # 77-700-100	Option Purified antibody	Volume 100 µL	Concentration 1 mg/mL	Price $335.00
Brand	Catalog # 77-700-020	Option Purified antibody-Trial size	Volume 20 µL	Concentration 1 mg/mL	Price $115.00

Validation Images

Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG1

Species Reactivity:

Chicken Frog Human Lizard Monkey Mouse Rat Vole Zebrafish

Applications:

ICC IHC IP WB

Target Description:

TH is the rate-limiting enzyme in the synthesis of the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine and is responsible for converting L-tyrosine to L-dopa. Synthesis of catecholamines is regulated by the interaction of TH with its’ cofactor, tetrahydrobiopterin (BH4) and the substrates L-tyrosine and molecular oxygen. In humans four TH mRNA splice variants (hTH1-hTH4) have been isolated while subprimate species rely on a single form of TH. It is known that the hTH1-hTH4 variants are identical in their catalytic domain but differ in their N-terminal regulatory domains. Importantly, LNC1 reacts with the catalytic domain of TH and thus with all four isoforms of human TH. The role of TH in the synthesis of catecholamine neurotransmitters suggests a connection between the enzyme and a number of neuropathogenic diseases characterized by irregular catecholamine levels, such as Parkinson's disease, schizophrenia, and dystonia, as well as a variety of cardiovascular diseases.

Immunogen:

Tyrosine Hydroxylase purified from PC12 cells

Protein Name(s):

Tyrosine 3-monooxygenase

Gene Name(s):

TH, TYH, EC 1.14.16.2

Antibody Validation and Application Notes

This antibody has been validated using the following assays:

Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunohistochemistry:

Fluorescent immunohistochemistry of sections from human midbrain showed the expected staining of dopaminergic neurons.

Molecular Weight:

59-63 kDa

Quality Control

The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Citations and References

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