Products: Primary Antibodies
PRODUCT OPTIONS
★ Trial Size Available ★Brand | Catalog # | Option | Volume | Concentration | Price | |
---|---|---|---|---|---|---|
Brand![]() |
Catalog # 76-700-100 |
Option Ascites Fluid |
Volume 100 µL |
Concentration Ascites fluid |
Price $335.00 |
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Brand![]() |
Catalog # 76-700-020 |
Option Ascites Fluid-Trial size |
Volume 20 µL |
Concentration Ascites fluid |
Price $115.00 |
|
Brand![]() |
Catalog # 77-700-100 |
Option Purified antibody |
Volume 100 µL |
Concentration 1 mg/mL |
Price $335.00 |
|
Brand![]() |
Catalog # 77-700-020 |
Option Purified antibody-Trial size |
Volume 20 µL |
Concentration 1 mg/mL |
Price $115.00 |
Product Details
Monoclonal
Mouse
IgG1
Chicken Frog Human Lizard Monkey Mouse Rat Vole Zebrafish
ICC IHC IP WB
TH is the rate-limiting enzyme in the synthesis of the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine and is responsible for converting L-tyrosine to L-dopa. Synthesis of catecholamines is regulated by the interaction of TH with its’ cofactor, tetrahydrobiopterin (BH4) and the substrates L-tyrosine and molecular oxygen. In humans four TH mRNA splice variants (hTH1-hTH4) have been isolated while subprimate species rely on a single form of TH. It is known that the hTH1-hTH4 variants are identical in their catalytic domain but differ in their N-terminal regulatory domains. Importantly, LNC1 reacts with the catalytic domain of TH and thus with all four isoforms of human TH. The role of TH in the synthesis of catecholamine neurotransmitters suggests a connection between the enzyme and a number of neuropathogenic diseases characterized by irregular catecholamine levels, such as Parkinson's disease, schizophrenia, and dystonia, as well as a variety of cardiovascular diseases.
Tyrosine Hydroxylase purified from PC12 cells
Tyrosine 3-monooxygenase
TH, TYH, EC 1.14.16.2
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
59-63 kDa
Quality Control
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
Citations and References
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