Anti-Laforin Antibody (N84/37)

Name: Anti-Laforin Antibody
Brand: NeuroMab
SKU: 75-222
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

1 Citation

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Human

Clone

N84/37

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

EPM2A

Molecular Weight

40 kDa

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$Immunoblot against crude membrane fractions from whole rat (RBM) or mouse (MBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N84/37 (left) or N52A/42 (right) TC supe.$

Immunoblot against crude membrane fractions from whole rat (RBM) or mouse (MBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N84/37 (left) or N52A/42 (right) TC supe.

Volume: 100 µL

Variant

Price:

$308

Quantity:

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Product Details

Target

Laforin

Target Description

Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) is encoded by the gene EPM2A. EPM2A is a member of the protein-tyrosine phosphatase family. EPM2A is a dual-specificity phosphatase that acts on complex carbohydrates to prevent glycogen hyperphosphorylation and the formation of insoluble aggregates. EPM2A promotes the ubiquitination of proteins involved in glycogen metabolism via its interactions with the E3 ubiquitin ligase NHLRC1/malin. EPM2A is expressed in the heart, skeletal muscle, kidney, pancreas, and the brain. Diseases associated with EPM2A include Myoclonic Epilepsy of Lafora, Myoclonic Epilepsy of Unverricht And Lundborg, and benign epilepsy with centrotemporal spikes.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N84/37

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

EPM2A

Molecular Weight

40 kDa

Antigen

Fusion protein amino acids 1-331 (full-length) of human Laforin (accession number O095278) produced recombinantly in E. Coli

Species Reactivity

Human

Antibody Registry ID

AB_11001826

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Laforin (EC 3.1.3.-) (EC 3.1.3.16) (EC 3.1.3.48) (Glucan phosphatase) (Glycogen phosphatase) (Lafora PTPase) (LAFPTPase)

UniProt Details

UniProt (Human): O95278
UniProt (Immunogen Species): O95278

Sherwood AR, Johnson MB, Delgado-Escueta AV, Gentry MS. (2013), 'A bioassay for Lafora disease and laforin glucan phosphatase activity..' Clinical Biochemistry. 10.1016/j.clinbiochem.2013.08.016.

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Anti-Laforin Antibody (N84/37)

Available Conjugates

Anti-Laforin Antibody
SKU: 75-222

Bulk Order Anti-Laforin Antibody

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Anti-Laforin Antibody (N84/37)

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Anti-Laforin Antibody SKU: 75-222

Bulk Order Anti-Laforin Antibody

Product Details

Anti-Laforin Antibody
SKU: 75-222