Anti-Laforin Antibody (N84/37)

Name: Anti-Laforin Antibody
Brand: NeuroMab
SKU: 75-222
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

ICC, WB

Host Species

Mouse

Gene Name

EPM2A

Molecular Weight

40 kDa

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$Immunoblot against crude membrane fractions from whole rat (RBM) or mouse (MBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N84/37 (left) or N52A/42 (right) TC supe.$

Immunoblot against crude membrane fractions from whole rat (RBM) or mouse (MBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N84/37 (left) or N52A/42 (right) TC supe.

Product Details

Target

Laforin

Target Description

Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) is encoded by the gene EPM2A. EPM2A is a member of the protein-tyrosine phosphatase family. EPM2A is a dual-specificity phosphatase that acts on complex carbohydrates to prevent glycogen hyperphosphorylation and the formation of insoluble aggregates. EPM2A promotes the ubiquitination of proteins involved in glycogen metabolism via its interactions with the E3 ubiquitin ligase NHLRC1/malin. EPM2A is expressed in the heart, skeletal muscle, kidney, pancreas, and the brain. Diseases associated with EPM2A include Myoclonic Epilepsy of Lafora, Myoclonic Epilepsy of Unverricht And Lundborg, and benign epilepsy with centrotemporal spikes.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N84/37

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

EPM2A

Molecular Weight

40 kDa

Antigen

Fusion protein amino acids 1-331 (full-length) of human Laforin (also known as Lafora PTPase, LAFPTPase and EPM2A, accession number O095278); Rat: 90% identity (296/327 amino acids identical); Mouse: 89% identity (295/327 amino acids identical)

Species Reactivity

Human

Antibody Registry ID

AB_11001826

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Laforin (EC 3.1.3.-) (EC 3.1.3.16) (EC 3.1.3.48) (Glucan phosphatase) (Glycogen phosphatase) (Lafora PTPase) (LAFPTPase)

UniProt Details

UniProt (Human): O95278
UniProt (Immunogen Species): O95278

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Anti-Laforin Antibody (N84/37)

Anti-Laforin Antibody
SKU: 75-222

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