Immunoblot against crude brain membrane preparations from adult rat (RBM) or wild-type (WT) or KA2 knockout (KO) mice probed with N279B/27 (left) or N52A/42 (right) TC supe. Mouse brains courtesy of Anis Contractor (Northwestern University.
Glutamate Ionotropic Receptor Kainate Type Subunit 5 is encoded by the gene GRIK5. GRIK5 is a member of the glutamate-gated ion channel (TC 1.A.10.1) family, GRIK5 subfamily. GRIK5 forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. GRIK5 is highly expressed in the cerebral cortex, pyriform cortex, caudate-putamen, hippocampal complex, medial habenulata, and granule cell layer of the cerebellum. GRIK5 is weakly expressed in the globus pallidus, thalamus, colliculi, and the reticular thalamic nucleus. Diseases associated with GRIK5 include Schizophrenia and Autosomal Recessive Non-Syndromic Intellectual Disability.
ICC, IHC, WB
Fusion protein amino acids 825-979 (cytoplasmic C-terminus) of rat KA2 kainate receptor (also known as Glutamate receptor ionotropic, kainate 5, Glutamate receptor gamma-2, GluR gamma-2, Excitatory amino acid receptor 2, Grik5, GluK5 and EAA2, accession number Q63273) Mouse: 100% identity (155/155 amino acids identical) Human: 95% identity (149/156 amino acids identical) Less than 50% identity with KA1
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not cross-react with KA1
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.