Anti-KA2 Kainate Receptor Antibody (N279B/27)

Name: Anti-KA2 Kainate Receptor Antibody
Brand: NeuroMab
SKU: 75-362
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N279B/27

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

Grik5

Molecular Weight

110 kDa

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Immunoblot against crude brain membrane preparations from adult rat (RBM) or wild-type (WT) or KA2 knockout (KO) mice probed with N279B/27 (left) or N52A/42 (right) TC supe. Mouse brains courtesy of Anis Contractor (Northwestern University.

Volume: 100 µL

Variant

Price:

$308

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Product Details

Target

Glutamate receptor ionotropic, kainate 5 (GluK5) (Glutamate receptor KA-2) (KA2)

Target Description

Glutamate Ionotropic Receptor Kainate Type Subunit 5 is encoded by the gene GRIK5. GRIK5 is a member of the glutamate-gated ion channel (TC 1.A.10.1) family, GRIK5 subfamily. GRIK5 forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. GRIK5 is highly expressed in the cerebral cortex, pyriform cortex, caudate-putamen, hippocampal complex, medial habenulata, and granule cell layer of the cerebellum. GRIK5 is weakly expressed in the globus pallidus, thalamus, colliculi, and the reticular thalamic nucleus. Diseases associated with GRIK5 include Schizophrenia and Autosomal Recessive Non-Syndromic Intellectual Disability.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N279B/27

Isotype

IgG2a

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Grik5

Molecular Weight

110 kDa

Antigen

Fusion protein amino acids 825-979 (cytoplasmic C-terminus) of rat KA2 kainate receptor (also known as Glutamate receptor ionotropic, kainate 5, Glutamate receptor gamma-2, GluR gamma-2, Excitatory amino acid receptor 2, Grik5, GluK5 and EAA2, accession number Q63273) Mouse: 100% identity (155/155 amino acids identical) Human: 95% identity (149/156 amino acids identical) Less than 50% identity with KA1

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2315855

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with KA1

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Glutamate receptor ionotropic, kainate 5 (GluK5) (Glutamate receptor KA-2) (KA2)

UniProt Details

UniProt (Human): Q16478
UniProt (Immunogen Species): Q63273

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Anti-KA2 Kainate Receptor Antibody (N279B/27)

Anti-KA2 Kainate Receptor Antibody
SKU: 75-362

Bulk Order Anti-KA2 Kainate Receptor Antibody

Product Details

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Anti-KA2 Kainate Receptor Antibody (N279B/27)

Anti-KA2 Kainate Receptor Antibody SKU: 75-362

Bulk Order Anti-KA2 Kainate Receptor Antibody

Product Details

Anti-KA2 Kainate Receptor Antibody
SKU: 75-362