Anti-ICK Antibody (N451/73)

Name: Anti-ICK Antibody
Brand: NeuroMab
SKU: 75-437
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N451/73

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

Ick

Molecular Weight

70 kDa

Go to Full Product Details

Adult rat hippocampus immunohistochemistry.

Volume: 100 µL

Variant

Price:

$308

Quantity:

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Product Details

Target

Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK)

Target Description

Serine/threonine-protein kinase ICK is encoded by the gene Ick. Ick is a member of the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. Ick has an essential role in ciliogenesis. Ick is envolved in the control of ciliary length by regulating the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. Ick is highly expressed in the colon and lungs, with lower levels of expression in the heart, esophagus, stomach, small intestine, and ovaries. Diseases associated with Ick include endocrine-cerebroosteodysplasia, juvenile myoclonic epilepsy 10, and juvenile myoclonic epilepsy 1.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N451/73

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Ick

Molecular Weight

70 kDa

Antigen

Fusion protein amino acids 290-629 (C-terminus) of mouse ICK (also known as Intestinal cell kinase, Laryngeal cancer kinase 2, MAK-related kinase, LCK2, MRK and KIAA0936, accession number Q9JKV2); Rat: 90% identity (307/340 amino acids identical); Human: 79% identity (264/335 amino acids identical); 40% identity with other kinases

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2576198

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK)

UniProt Details

UniProt (Human): Q9UPZ9
UniProt (Immunogen Species): Q9JKV2

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Anti-ICK Antibody (N451/73)

Anti-ICK Antibody
SKU: 75-437

Bulk Order Anti-ICK Antibody

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