Anti-HCN3 Antibody (N141/28)

Name: Anti-HCN3 Antibody
Brand: NeuroMab
SKU: 75-175
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

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Clonality

Monoclonal

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Hcn3 Hac3

Molecular Weight

90 kDa

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Immunoblot versus lysates of total brain from HCN3 knockout (KO) and wild-type (WT) mice probed with N141/28. Data courtesy of Martin Biel (Ludwig-Maximilians Universität München) and reproduced from the Journal of Biological Chemistry (2013 Cao-Ehlker et al, PMID 23382386).

Adult rat hippocampus immunohistochemistry.

Immunoblot versus lysates of total brain from HCN3 knockout (KO) and wild-type (WT) mice probed with N141/28. Data courtesy of Martin Biel (Ludwig-Maximilians Universität München) and reproduced from the Journal of Biological Chemistry (2013 Cao-Ehlker et al, PMID 23382386).

Product Details

Target

HCN3

Target Description

HCN3 is a member of the hyperpolarization-activated cyclic nucleotide gated channel family, also known as pacemaker channels. This family has a role in rhythmic activity of the heart and firing neurons. HCN channels are made up of four subunits, HCN1-4 and can be formed in multiple combinations HCN3 is found in brain, heart, skeletal muscle and lung.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N141/28

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Hcn3 Hac3

Molecular Weight

90 kDa

Antigen

Fusion protein amino acids 660-779 (cytoplasmic C-terminus) of mouse HCN3(also known as potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3, hyperpolarization-activated cation channel 3 and HAC-3, accession number O88705); Rat: 98% identity (118/120 amino acids identical) Human: 86% identity (105/121 amino acids identical) Less than 50% identity with HCN1, HCN2 and HCN4

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2120025

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity against other HCN’s

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3)

UniProt Details

UniProt (Human): Q9P1Z3
UniProt (Immunogen Species): O88705

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Anti-HCN3 Antibody (N141/28)

Anti-HCN3 Antibody
SKU: 75-175

Product Details

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Anti-HCN3 Antibody (N141/28)

Anti-HCN3 Antibody SKU: 75-175

Product Details

Anti-HCN3 Antibody
SKU: 75-175