G-protein coupled receptor kinase interacting ArfGAP 2 is encoded by the gene GIT2. GIT2 is a member of the GIT protein family. GIT2 has a be shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. GIT2 is expressed in 207 organs with the highest expression level in the right hemisphere of cerebellum. Diseases associated with GIT2 include Gastric Antral Vascular Ectasia and Systemic Scleroderma.
Purified by Protein A chromatography
ICC, IHC, IP, WB
Fusion protein amino acids 450-759 (C-terminus) of human GIT2 (accession number Q14161) produced recombinantly in E. Coli
Human, Mouse, Rat
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.53
No cross-reactivity against GIT1
Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from date of receipt
Shipped on ice packs
ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)