G-protein coupled receptor kinase interacting ArfGAP 2 is encoded by the gene GIT2. GIT2 is a member of the GIT protein family. GIT2 has a be shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. GIT2 is expressed in 207 organs with the highest expression level in the right hemisphere of cerebellum. Diseases associated with GIT2 include Gastric Antral Vascular Ectasia and Systemic Scleroderma.
IHC, IP, WB
Fusion protein amino acids 450-759 (C-terminus) of human GIT2 (also known as ARF GTPaseactivating protein, G protein-coupled receptor kinase-interactor 2, GRK-interacting protein 2,Cool-interacting tyrosine-phosphorylated protein 2 and CAT2, accession number Q14161); Mouse: 88% identity (263/298 amino acids identical); Less than 50% identity with GIT1
Human, Mouse, Rat
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