Anti-GFAP-R416WT Antibody (N206B/9)

Name: Anti-GFAP-R416WT Antibody
Brand: NeuroMab
SKU: 75-279
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

N206B/9

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

GFAP

Molecular Weight

50 kDa

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KC rabbit anti- Kv2.1 Brain samples courtesy of Albee Messing, UW- Madison.

Immunofluorescence of GFAP WT and KO mouse hippocampus with N206B/9 Brain samples courtesy of Albee Messing, UW- Madison.

Immunoblot versus brain samples from adult rat (RBLSP) and GFAP wild- type (WT), knockout (KO) and R416W KI mice. Mutant control courtesy of Michael Brenner, UAB.

KC rabbit anti- Kv2.1 Brain samples courtesy of Albee Messing, UW- Madison.

Volume: 100 µL

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$308

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Product Details

Target

Glial fibrillary acidic protein (GFAP)

Target Description

Glial Fibrillary Acidic Protein (GFAP) was discovered by Amico Bignami and co-workers as a major fibrous protein of multiple sclerosis plaques. It was subsequently found to be a member of the 10nm or intermediate filament (IF) family, specifically the IF family Class III, which also includes peripherin, desmin and vimentin. GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the CNS, in satellite cells, peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition, neural stem cells frequently strongly express GFAP. Point mutations in the protein coding region of the GFAP gene lead to Alexander disease which is characterized by the presence of abnormal astrocytes containing GFAP protein aggregates known as Rosenthal fibers .

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N206B/9

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

GFAP

Molecular Weight

50 kDa

Antigen

Synthetic peptide amino acids 411-422 (KTVEMRDGEVIK) of human GFAP (also known as Glial fibrillary acidic protein, accession number P14136); Rat: 100% identity (12/12 amino acids identical); Mouse: 100% identity (12/12 amino acids identical) 50% identity with other proteins (Vimentin, Desmin and Peripherin)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_11000169

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with GFAP-R416W or other proteins (based on KO validation results)

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Glial fibrillary acidic protein (GFAP)

UniProt Details

UniProt (Human): P14136
UniProt (Immunogen Species): P14136

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Anti-GFAP-R416WT Antibody (N206B/9)

Anti-GFAP-R416WT Antibody
SKU: 75-279

Bulk Order Anti-GFAP-R416WT Antibody

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Anti-GFAP-R416WT Antibody (N206B/9)

Anti-GFAP-R416WT Antibody SKU: 75-279

Bulk Order Anti-GFAP-R416WT Antibody

Product Details

Anti-GFAP-R416WT Antibody
SKU: 75-279