Anti-GABA(A)R, Beta3 Antibody (N87/25)

Name: Anti-GABA(A)R, Beta3 Antibody
Brand: NeuroMab
SKU: 75-149
Price: 285.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Gabrb3 Gabrb-3

Molecular Weight

55 kDa

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Immunofluorescence of cultured hippocampal neurons with N87/25 (red) and GABA-A-R-Gamma2 rabbit polyclonal (green). Images courtesy of Angel de Blas (University of Connecticut)..

Adult rat hippocampus immunohistochemistry.

Whole adult rat brain immunohistochemistry.

$Immunoblot against membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with N87/25 (left) or N52A/42 (right) TC supe.$

Adult rat brain membrane immunoblot.

Product Details

Target

GABA(A)R, Beta3

Target Description

Gamma-aminobutyric acid receptor subunit beta-3 or GABA AR-Beta3 is encoded by the gene GABRB3. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR-beta3 a is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR beta3 has been found to be expressed in retina, heart and primarily in brain at the cell junction, synapse, postsynaptic cell membrane and cytoplasmic vesicle membrane. This gene may be associated with the pathogenesis of several disorders including epilepsy and autism, childhood absence epilepsy 5 and early infantile epileptic encephalopathy 43.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N87/25

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Gabrb3 Gabrb-3

Molecular Weight

55 kDa

Antigen

Fusion protein amino acids 370-433 of mouse GABA-A-R-Beta3 (also known as gamma-aminobutyric acid receptor subunit beta-3, accession number AAB60502); Rat: 100% identity (64/64 amino acids identical); Human: 85% identity (53/64 amino acids identical); Less than 40% identity with GABA-A-R-Beta1 or -Beta2

Species Reactivity

Human, Mouse

Antibody Registry ID

AB_2109585

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity against GABA-A-R-Beta1 or –Beta2

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3)

UniProt Details

UniProt (Human): P28472
UniProt (Immunogen Species): P63080

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Anti-GABA(A)R, Beta3 Antibody (N87/25)

Anti-GABA(A)R, Beta3 Antibody
SKU: 75-149

Product Details

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Anti-GABA(A)R, Beta3 Antibody (N87/25)

Anti-GABA(A)R, Beta3 Antibody SKU: 75-149

Product Details

Anti-GABA(A)R, Beta3 Antibody
SKU: 75-149