Dopamine D2 receptor is encoded by the gene DRD2. DRD2 is a member of the G-protein coupled receptor 1 family that also includes D1, D3, D4 and D5. This G-protein coupled receptor inhibits adenylyl cyclase activity. DRD2 is expressed in the brain, colon, testis, and skeletal muscle tissue. Diseases associated with DRD2 include cocaine dependence, pathological gambling, and delusional disorder.
Fusion protein amino acids 211-374 (cytoplasmic, long form) of rat Dopamine D2 receptor (also known as Drd2, accession number P61169); Mouse: 100% identity (164/164 amino acids identical); Human: 92% identity (152/164 amino acids identical); Greater than 80% identity with Short form; Less than 25% identity with Dopamine D3 receptor
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