Anti-Dopamine D2 Receptor Antibody (N186/29)

Name: Anti-Dopamine D2 Receptor Antibody
Brand: NeuroMab
SKU: 75-230
Price: 319.0 USD
Availability: InStock

1 Citation

Our Anti-Dopamine D2 receptor mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N186/29. It detects mouse and rat Dopamine D2 receptor, and is purified by Protein A chromatography. It is great for use in IHC.

Adult rat striatum immunohistochemistry.

Species Reactivity

Mouse, Rat

Applications

IHC

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-230

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

Dopamine D2 receptor

Target Description

Dopamine D2 receptor is encoded by the gene DRD2. DRD2 is a member of the G-protein coupled receptor 1 family that also includes D1, D3, D4 and D5. This G-protein coupled receptor inhibits adenylyl cyclase activity. DRD2 is expressed in the brain, colon, testis, and skeletal muscle tissue. Diseases associated with DRD2 include cocaine dependence, pathological gambling, and delusional disorder.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N186/29

Isotype

IgG1

Applications

IHC

Host Species

Mouse

Gene Name

Drd2

Molecular Weight

50 kDa

Antigen

Fusion protein amino acids 211-374 (cytoplasmic, long form) of rat Dopamine D2 receptor (accession number P61169) produced recombinantly in E. Coli

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_11000721

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Reacts with both Long and Short formsDoes not cross-react with Dopamine D3 receptor

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

D(2) dopamine receptor (Dopamine D2 receptor)

UniProt Details

UniProt (Human): P14416
UniProt (Immunogen Species): P61169

Escobar AP, González MP, Meza RC, Noches V, Henny P, Gysling K, España RA, Fuentealba JA, Andrés ME. (2017), 'Mechanisms of Kappa Opioid Receptor Potentiation of Dopamine D2 Receptor Function in Quinpirole-Induced Locomotor Sensitization in Rats..' The International Journal of Neuropsychopharmacology. 10.1093/ijnp/pyx042.

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Anti-Dopamine D2 Receptor Antibody (N186/29)

SKU: 75-230

Product Details

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