Anti-Cavbeta1 Ca2+ Channel Antibody (N7/18)

Name: Anti-Cavbeta1 Ca2+ Channel Antibody
Brand: NeuroMab
SKU: 75-052
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

CACNB1 CACNLB1

Molecular Weight

80, 55 kDa

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Adult rat hippocampus immunohistochemistry.

Adult rat whole brain immunohistochemistry.

$Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with N7/18 (left) or N52A/42 (right) TC supe.$

Adult rat hippocampus immunohistochemistry.

Product Details

Target

Cavbeta1 Ca2+ channel

Target Description

Voltage-dependent L-type calcium channel subunit beta-1 or Cav ß1 is encoded by the gene CACNB1. Cavß1 is a cytoplasmic subunit of L type voltage-sensitive calcium channels. These channels facilitate entry of calcium ions into excitable cells are involved in a variety of calcium dependent processes, including neurotransmitter release, muscle contraction, and gene expression. Cavß1 serves to regulate the activity of L-type calcium channels. Cavß1 expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Diseases associated with CACNB1 include Malignant Hyperthermia and epileptic encephalopathy.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N7/18

Isotype

IgG2a

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

CACNB1 CACNLB1

Molecular Weight

80, 55 kDa

Antigen

Synthetic peptide amino acids 19-34 of rat Cav1 (PMEVFDPSPQGKYSKR; NP_059042); Human: 100% identity; Mouse: 100% identity; Common to all splice variants

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2243972

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with Cavβ2, Cavβ3, Cavβ4

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1)

UniProt Details

UniProt (Human): Q02641
UniProt (Immunogen Species): Q02641

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Anti-Cavbeta1 Ca2+ Channel Antibody (N7/18)

Anti-Cavbeta1 Ca2+ Channel Antibody
SKU: 75-052

Product Details

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Anti-Cavbeta1 Ca2+ Channel Antibody (N7/18)

Anti-Cavbeta1 Ca2+ Channel Antibody SKU: 75-052

Product Details

Anti-Cavbeta1 Ca2+ Channel Antibody
SKU: 75-052