Voltage-dependent L-type calcium channel subunit beta-1 or Cav ß1 is encoded by the gene CACNB1. Cavß1 is a cytoplasmic subunit of L type voltage-sensitive calcium channels. These channels facilitate entry of calcium ions into excitable cells are involved in a variety of calcium dependent processes, including neurotransmitter release, muscle contraction, and gene expression. Cavß1 serves to regulate the activity of L-type calcium channels. Cavß1 expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Diseases associated with CACNB1 include Malignant Hyperthermia and epileptic encephalopathy.
IHC, IP, WB
80, 55 kDa
Synthetic peptide amino acids 19-34 of rat Cav1 (PMEVFDPSPQGKYSKR; NP_059042); Human: 100% identity; Mouse: 100% identity; Common to all splice variants
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not cross-react with Cavβ2, Cavβ3, Cavβ4
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.