Voltage-dependent L-type calcium channel subunit alpha-1D, or Cav1.3 calcium channel is a calcium channel encoded by the gene CACNA1D. It is a member of the L type voltage dependent calcium channel family. These calcium channels mediate the influx of calcium ions into a cell upon membrane polarization. Cav1.3 is expressed primarily in the membrane of the heart, brain (cerebral cortex, hippocampus, basal ganglia and thalamus). and pancreatic islets. Calcium channels are involved in many cell processes including muscle contraction, neurotransmitter release, gene expression, cell division and cell death. Diseases associated with Cav1.3 include Primary Aldosteronism, Seizures, Sinoatrial Node Dysfunction and Deafness.
ICC, IHC, WB
Cacna1d Cach3 Cacn4 Cacnl1a2 Cchl1a2
Fusion protein amino acids 2025-2161 (C-terminus) of rat Cav1.3 (also known as voltagedependent L-type calcium channel subunit alpha-1D, RAT brain class D and RBD, accession number P27732); Mouse: 99% identity (136/137 amino acids identical); Human: 94% identity (130/137 amino acids identical); 50% identity with Cav1.2
Human, Mouse, Rat
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