Anti-Cav1.3 Ca2+ Channel Antibody (N38/8)

Name: Anti-Cav1.3 Ca2+ Channel Antibody
Brand: NeuroMab
SKU: 75-080
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet

20 Citations

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

N38/8

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

Cacna1d Cach3 Cacn4 Cacnl1a2 Cchl1a2

Molecular Weight

>220 kDa

Go to Full Product Details

Adult rat hippocampus immunohistochemistry.

Volume: 100 µL

Variant

Price:

$295

Quantity:

Bulk Order Anti-Cav1.3 Ca2+ Channel Antibody

Product Details

Target

Cav1.3 Ca2+ channel

Target Description

Voltage-dependent L-type calcium channel subunit alpha-1D, or Cav1.3 calcium channel is a calcium channel encoded by the gene CACNA1D. It is a member of the L type voltage dependent calcium channel family. These calcium channels mediate the influx of calcium ions into a cell upon membrane polarization. Cav1.3 is expressed primarily in the membrane of the heart, brain (cerebral cortex, hippocampus, basal ganglia and thalamus). and pancreatic islets. Calcium channels are involved in many cell processes including muscle contraction, neurotransmitter release, gene expression, cell division and cell death. Diseases associated with Cav1.3 include Primary Aldosteronism, Seizures, Sinoatrial Node Dysfunction and Deafness.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N38/8

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Cacna1d Cach3 Cacn4 Cacnl1a2 Cchl1a2

Molecular Weight

>220 kDa

Antigen

Fusion protein amino acids 2025-2161 (C-terminus) of rat Cav1.3 (also known as voltagedependent L-type calcium channel subunit alpha-1D, RAT brain class D and RBD, accession number P27732); Mouse: 99% identity (136/137 amino acids identical); Human: 94% identity (130/137 amino acids identical); 50% identity with Cav1.2

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_10673964

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with Cav1.2

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2) (Rat brain class D) (RBD) (Voltage-gated calcium channel subunit alpha Cav1.3)

UniProt Details

UniProt (Human): Q01668
UniProt (Immunogen Species): P27732

Product Specific References for Applications and Species

Immunocytochemistry: Mouse | Rat
Immunohistochemistry: Human | Mouse | Rat
Western Blot: Human | Mouse |Rat

Immunocytochemistry: Mouse
PMID	Dilution	Publication
23576958	not listed	Ginger, M., et al. 2013. Three-dimensional tracking and analysis of ion channel signals across dendritic arbors. Frontiers in neural circuits, 61.
23229576	1:100	Liedtke, W., et al. 2013. Highly conductive carbon nanotube matrix accelerates developmental chloride extrusion in central nervous system neurons by increased expression of chloride transporter KCC2. Small (Weinheim an der Bergstrasse, Germany), 1066-1075.
21281707	1:100	Chen, W., et al. 2011. Complex distribution patterns of voltage-gated calcium channel α-subunits in the spiral ganglion. Hearing research, 52-68.

Immunocytochemistry: Rat
PMID	Dilution	Publication
23229576	1:100	Liedtke, W., et al. 2013. Highly conductive carbon nanotube matrix accelerates developmental chloride extrusion in central nervous system neurons by increased expression of chloride transporter KCC2. Small (Weinheim an der Bergstrasse, Germany), 1066-1075.

Immunohistochemistry: Human
PMID	Dilution	Publication
27098837	1:500	Xie, C., et al. 2016. Regulation of aldosterone secretion by Cav1.3. Scientific reports, 24697.
23771339	1:100	Hurley, M., et al. 2013. Parkinson's disease is associated with altered expression of CaV1 channels and calcium-binding proteins. Brain : a journal of neurology, 2077-2097.
19778450	not listed	Bernstein, S., et al. 2009. Expressed sequence tag analysis of adult human optic nerve for NEIBank: identification of cell type and tissue markers. BMC neuroscience, 121.

Immunohistochemistry: Mouse
PMID	Dilution	Publication
27932504	1:100	Radhakrishnan, V., et al. 2017. Expression of Cav1.3 calcium channel in the human and mouse colon: posttranscriptional inhibition by IFNγ. American journal of physiology. Gastrointestinal and liver physiology, G77-G84.

Immunohistochemistry: Rat
PMID	Dilution	Publication
24033980	not listed	Núñez-Santana, F., et al. 2014. Surface L-type Ca2+ channel expression levels are increased in aged hippocampus. Aging cell, 111-120.

Western Blot: Human
PMID	Dilution	Publication
23913004	1:500	Azizan, E., et al. 2013. Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nature genetics, 1055-1060.
23771339	not listed	Hurley, M., et al. 2013. Parkinson's disease is associated with altered expression of CaV1 channels and calcium-binding proteins. Brain : a journal of neurology, 2077-2097.
19778450	not listed	Bernstein, S., et al. 2009. Expressed sequence tag analysis of adult human optic nerve for NEIBank: identification of cell type and tissue markers. BMC neuroscience, 121.

Western Blot: Mouse
PMID	Dilution	Publication
27932504	not listed	Radhakrishnan, V., et al. 2017. Expression of Cav1.3 calcium channel in the human and mouse colon: posttranscriptional inhibition by IFNγ. American journal of physiology. Gastrointestinal and liver physiology, G77-G84.
25538241	not listed	Lu, L., et al. 2015. Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3. The Journal of biological chemistry, 4663-4676.
22892111	1:1000	Zou, J., et al. 2012. The expression of whirlin and Cav1.3α₁ is mutually independent in photoreceptors. Vision research, 53-59.
22133878	not listed	Goonasekera, S., et al. 2012. Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice. The Journal of clinical investigation, 280-290.
21940447	1:1000	Schierberl, K., et al. 2011. Cav1.2 L-type Ca²⁺ channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels. The Journal of neuroscience : the official journal of the Society for Neuroscience, 13562-13575.
21281707	not listed	Chen, W., et al. 2011. Complex distribution patterns of voltage-gated calcium channel α-subunits in the spiral ganglion. Hearing research, 52-68.

Western Blot: Rat
PMID	Dilution	Publication
24033980	not listed	Núñez-Santana, F., et al. 2014. Surface L-type Ca2+ channel expression levels are increased in aged hippocampus. Aging cell, 111-120.
23457553	1:4 (supe)	Bissig, B., et al. 2013. Diminished vision in healthy aging is associated with increased retinal L-type voltage gated calcium channel ion influx. PloS one, e56340.

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Anti-Cav1.3 Ca2+ Channel Antibody (N38/8)

Anti-Cav1.3 Ca2+ Channel Antibody
SKU: 75-080

Bulk Order Anti-Cav1.3 Ca2+ Channel Antibody

Product Details

Product Specific References for Applications and Species

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Anti-Cav1.3 Ca2+ Channel Antibody (N38/8)

Anti-Cav1.3 Ca2+ Channel Antibody SKU: 75-080

Bulk Order Anti-Cav1.3 Ca2+ Channel Antibody

Product Details

Product Specific References for Applications and Species

Anti-Cav1.3 Ca2+ Channel Antibody
SKU: 75-080