Anti-Cav1.3 Ca2+ Channel Antibody (N38/8)

Name: Anti-Cav1.3 Ca2+ Channel Antibody
Brand: NeuroMab
SKU: 75-080
Price: 295.0 USD
Availability: InStock

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Clonality

Monoclonal

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Cacna1d Cach3 Cacn4 Cacnl1a2 Cchl1a2

Molecular Weight

>220 kDa

Go to Full Product Details

Adult rat hippocampus immunohistochemistry.

Product Details

Target

Cav1.3 Ca2+ channel

Target Description

Voltage-dependent L-type calcium channel subunit alpha-1D, or Cav1.3 calcium channel is a calcium channel encoded by the gene CACNA1D. It is a member of the L type voltage dependent calcium channel family. These calcium channels mediate the influx of calcium ions into a cell upon membrane polarization. Cav1.3 is expressed primarily in the membrane of the heart, brain (cerebral cortex, hippocampus, basal ganglia and thalamus). and pancreatic islets. Calcium channels are involved in many cell processes including muscle contraction, neurotransmitter release, gene expression, cell division and cell death. Diseases associated with Cav1.3 include Primary Aldosteronism, Seizures, Sinoatrial Node Dysfunction and Deafness.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N38/8

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Cacna1d Cach3 Cacn4 Cacnl1a2 Cchl1a2

Molecular Weight

>220 kDa

Antigen

Fusion protein amino acids 2025-2161 (C-terminus) of rat Cav1.3 (also known as voltagedependent L-type calcium channel subunit alpha-1D, RAT brain class D and RBD, accession number P27732); Mouse: 99% identity (136/137 amino acids identical); Human: 94% identity (130/137 amino acids identical); 50% identity with Cav1.2

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_10673964

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with Cav1.2

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2) (Rat brain class D) (RBD) (Voltage-gated calcium channel subunit alpha Cav1.3)

UniProt Details

UniProt (Human): Q01668
UniProt (Immunogen Species): P27732

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Anti-Cav1.3 Ca2+ Channel Antibody (N38/8)

Anti-Cav1.3 Ca2+ Channel Antibody
SKU: 75-080

Product Details

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Anti-Cav1.3 Ca2+ Channel Antibody (N38/8)

Anti-Cav1.3 Ca2+ Channel Antibody SKU: 75-080

Product Details

Anti-Cav1.3 Ca2+ Channel Antibody
SKU: 75-080