Anti-Ataxin-1, WT Antibody (N65/37)

Name: Anti-Ataxin-1, WT Antibody
Brand: NeuroMab
SKU: 75-102
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

N65/37

Applications

ICC, WB

Host Species

Mouse

Format

Purified

Gene Name

Atxn1 Sca1

Molecular Weight

85 kDa

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Adult rat hippocampus immunohistochemistry.

Transfected cell immunoblot: extracts of COS-1 cells transfected with Ataxin- 1-WT, Ataxin-1-S751A or Kv2.1 plasmid and probed with N65/37 TC supe.

Adult rat cerebellum immunohistochemistry.

Adult rat hippocampus immunohistochemistry.

Volume: 100 µL

Variant

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Product Details

Target

Ataxin-1, WT

Target Description

Ataxin1, also known as spinocerebellar ataxia type 1 protein homolog, is a highly conserved DNA-binding protein. Ataxin1 is expressed in brain and can be found at high levels in the cortex and the hypothalamus in neurons. It is also expressed in other tissues. Within the cell, it is highly expressed in the nucleus, and can also be found in the cytoplasm. Mutations in the ataxin-1 gene cause spinocerebellar ataxia type 1.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N65/37

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

Atxn1 Sca1

Molecular Weight

85 kDa

Antigen

Synthetic peptide amino acids 746-761 (RKRRRWSAPETRKLEK) of mouse ataxin-1 (also known as spinocerebellar ataxia type 1 protein homolog, accession number P54254); Rat: 93% identity (15/16 amino acids identical); Human: 87% identity (14/16 amino acids identical)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_10675132

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Minimal cross-reactivity against S751A mutant of Ataxin-1 by ELISA and immunofluorescence and negative by immunoblot (right)

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog)

UniProt Details

UniProt (Human): P54253
UniProt (Immunogen Species): P54254

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Anti-Ataxin-1, WT Antibody (N65/37)

Anti-Ataxin-1, WT Antibody
SKU: 75-102

Bulk Order Anti-Ataxin-1, WT Antibody

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Anti-Ataxin-1, WT Antibody (N65/37)

Anti-Ataxin-1, WT Antibody SKU: 75-102

Bulk Order Anti-Ataxin-1, WT Antibody

Product Details

Anti-Ataxin-1, WT Antibody
SKU: 75-102