Anti-ANO6/TMEM16F Antibody (N429/19)

Name: Anti-ANO6/TMEM16F Antibody
Brand: NeuroMab
SKU: 75-418
Price: 329.0 USD
Availability: InStock

Our Anti-ANO6/TMEM16F mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N429/19. It is KO validated, detects human, mouse, and rat ANO6/TMEM16F, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Adult rat whole brain immunohistochemistry.

Immunoblot against lysates of wild-type (WT) and ANO6/TMEM16F knockout (KO) mouse embryonic fibroblasts probed with N429/19 TC supe. Data courtesy of Andrew Kim and Lily Jan (UCSF).

Adult rat whole brain immunohistochemistry.

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-418

Volume: 100 µL

Variant

Price:

$329.00

Quantity:

Ships: 1-2 business days

Product Details

Target

ANO6/TMEM16F

Target Description

Anoctamin-6, Transmembrane Protein 16F or -ANO6/TMEM16F is encoded by the gene ANO6. ANO6 belongs to the anoctamin family of membrane proteins many of which are calcium-activated chloride channels. ANO6 plays a role as a regulator of phospholipid scrambling in platelets (which is involved in blood clotting). ANO6 is expressed in epithelial tissues. Diseases associated with ANO6 include Scott Syndrome and Miyoshi Muscular Dystrophy 3.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N429/19

Isotype

IgG2b

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

ANO6 TMEM16F

Molecular Weight

110 kDa

Antigen

Fusion protein amino acids 1-294 (cytoplasmic N-terminus) of human ANO6 (accession number Q4KMQ2) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2491186

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Dilution Ranges

WB: 1:50

Conjugate

Unconjugated

Specificity

Does not cross-react with ANO5/TMEM16E

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F)

UniProt ID

Q4KMQ2

Product Specific References for Applications and Species

Western Blot: Mouse

Western Blot: Mouse
PMID	Dilution	Publication
26693275	1:40	Xu, J., et al. 2015. Genetic disruption of Ano5 in mice does not recapitulate human ANO5-deficient muscular dystrophy. Skeletal Muscle, 43.

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Anti-ANO6/TMEM16F Antibody (N429/19)

SKU: 75-418

Product Details

Product Specific References for Applications and Species

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