Anti-ANO6/TMEM16F Antibody (N429/19)

Name: Anti-ANO6/TMEM16F Antibody
Brand: NeuroMab
SKU: 75-418
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

1 Citation

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

N429/19

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

ANO6 TMEM16F

Molecular Weight

110 kDa

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Adult rat whole brain immunohistochemistry.

Immunoblot against lysates of wild-type (WT) and ANO6/TMEM16F knockout (KO) mouse embryonic fibroblasts probed with N429/19 TC supe. Data courtesy of Andrew Kim and Lily Jan (UCSF).

Adult rat whole brain immunohistochemistry.

Volume: 100 µL

Variant

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Product Details

Target

Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F)

Target Description

Anoctamin-6, Transmembrane Protein 16F or -ANO6/TMEM16F is encoded by the gene ANO6. ANO6 belongs to the anoctamin family of membrane proteins many of which are calcium-activated chloride channels. ANO6 plays a role as a regulator of phospholipid scrambling in platelets (which is involved in blood clotting). ANO6 is expressed in epithelial tissues. Diseases associated with ANO6 include Scott Syndrome and Miyoshi Muscular Dystrophy 3.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N429/19

Isotype

IgG2b

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

ANO6 TMEM16F

Molecular Weight

110 kDa

Antigen

Fusion protein amino acids 1-294 (cytoplasmic N-terminus) of human ANO6 (also known as Anoctamin-6, Small-conductance calcium-activated nonselective cation channel, SCAN channel, Transmembrane protein 16F, Tmem16f and rCG_50511, accession number Q4KMQ2); Mouse: 86% identity (256/296 amino acids identical); Rat: 81% identity (257/317 amino acids identical); 45% identity with ANO5/TMEM16E

Species Reactivity

Human, Mouse, Rat

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with ANO5/TMEM16E

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F)

UniProt Details

UniProt (Human): Q4KMQ2
UniProt (Immunogen Species): Q4KMQ2

Xu J, El Refaey M, Xu L, Zhao L, Gao Y, Floyd K, Karaze T, Janssen PM, Han R. (2015), 'Genetic disruption of Ano5 in mice does not recapitulate human ANO5-deficient muscular dystrophy.' Skelet Muscle. 10.1186/s13395-015-0069-z..

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Anti-ANO6/TMEM16F Antibody (N429/19)

Anti-ANO6/TMEM16F Antibody
SKU: 75-418

Bulk Order Anti-ANO6/TMEM16F Antibody

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Anti-ANO6/TMEM16F Antibody (N429/19)

Anti-ANO6/TMEM16F Antibody SKU: 75-418

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Anti-ANO6/TMEM16F Antibody
SKU: 75-418