Immunoblot against extracts of COS cells transiently transfected with untagged ANO5/TMEM16E, GFP- tagged ANO6/TMEM16F or untagged Kv2.1 plasmid probed with N421A/85 (left) or N86/38 (right) TC supe.
Anoctamin-5 (Gnathodiaphyseal dysplasia 1 protein) (Transmembrane protein 16E)
Anoctamin-5, Transmembrane Protein 16E or -ANO5/TMEM16E is encoded by the gene ANO5. ANO5 belongs to the anoctamin family of membrane proteins many of which are calcium-activated chloride channels. ANO5 does not exhibit this channel activity. ANO5 is expressed in brain, heart, kidney, lung, skeletal muscle as well as other tissues. Diseases associated with ANO5 include Gnathodiaphyseal Dysplasia and Miyoshi Muscular Dystrophy 3.
ANO5 GDD1 TMEM16E
Fusion protein amino acids 1-299 (cytoplasmic N-terminus) of human ANO5 (also known as Anoctamin-5, Gnathodiaphyseal dysplasia 1 protein, Transmembrane protein 16E, GDD1, TMEM16E and RGD1564265, accession number Q75V66); Rat: 80% identity (228/283 amino acids identical); Mouse: 77% identity (226/292 amino acids identical); 45% identity with ANO6/TMEM16F
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