Anti-ANO5/TMEM16E Antibody (N421A/85)

Name: Anti-ANO5/TMEM16E Antibody
Brand: NeuroMab
SKU: 75-410
Price: 361.0 USD
Availability: InStock

from NeuroMab Datasheet

2 Citations

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Human

Clone

N421A/85

Applications

ICC, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

ANO5 GDD1 TMEM16E

Molecular Weight

110 kDa

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Immunoblot against extracts of COS cells transiently transfected with untagged ANO5/TMEM16E, GFP- tagged ANO6/TMEM16F or untagged Kv2.1 plasmid probed with N421A/85 (left) or N86/38 (right) TC supe.

Volume: 100 µL

Variant

Price:

$361

Quantity:

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Product Details

Target

ANO5/TMEM16E

Target Description

Anoctamin-5, Transmembrane Protein 16E or -ANO5/TMEM16E is encoded by the gene ANO5. ANO5 belongs to the anoctamin family of membrane proteins many of which are calcium-activated chloride channels. ANO5 does not exhibit this channel activity. ANO5 is expressed in brain, heart, kidney, lung, skeletal muscle as well as other tissues. Diseases associated with ANO5 include Gnathodiaphyseal Dysplasia and Miyoshi Muscular Dystrophy 3.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N421A/85

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

ANO5 GDD1 TMEM16E

Molecular Weight

110 kDa

Antigen

Fusion protein amino acids 1-299 (cytoplasmic N-terminus) of human ANO5 (accession number Q75V66) produced recombinantly in E. Coli

Species Reactivity

Human

Antibody Registry ID

AB_2531893

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with ANO6/TMEM16F

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Anoctamin-5 (Gnathodiaphyseal dysplasia 1 protein) (Transmembrane protein 16E)

UniProt Details

UniProt (Human): Q75V66
UniProt (Immunogen Species): Q75V66

Griffin DA, Johnson RW, Whitlock JM, Pozsgai ER, Heller KN, Grose WE, Arnold WD, Sahenk Z, Hartzell HC, Rodino-Klapac LR. (2016), 'Defective membrane fusion and repair in Anoctamin5-deficient muscular dystrophy..' Hum Mol Genet. 10.1093/hmg/ddw063.
Vihola A, Luque H, Savarese M, Penttilä S, Lindfors M, Leturcq F, Eymard B, Tasca G, Brais B, Conte T, Charton K, Richard I, Udd B,. (2017), 'Diagnostic anoctamin-5 protein defect in patients with ANO5-mutated muscular dystrophy..' Neuropathol Appl Neurobiol.. 10.1111/nan.12410.

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Anti-ANO5/TMEM16E Antibody (N421A/85)

Available Conjugates

Anti-ANO5/TMEM16E Antibody
SKU: 75-410

Bulk Order Anti-ANO5/TMEM16E Antibody

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Anti-ANO5/TMEM16E Antibody (N421A/85)

Available Conjugates

Anti-ANO5/TMEM16E Antibody SKU: 75-410

Bulk Order Anti-ANO5/TMEM16E Antibody

Product Details

Anti-ANO5/TMEM16E Antibody
SKU: 75-410