Anti-Ankyrin-R Antibody (N388A/10)

Name: Anti-Ankyrin-R Antibody
Brand: NeuroMab
SKU: 75-380
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

KO Validated

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

N388A/10

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

ANK1 ANK

Molecular Weight

200 kDa

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Immunoblot against crude membranes from adult rat brain (RBM) and wild-type (WT) and Ankyrin-R knockout (KO) mouse brains probed with N388A/10 (left) and K58/35 (right) TC supe. Mouse brains courtesy of Matthew Rasband (Baylor College of Medicine.

Adult rat hippocampus immunohistochemistry.

Volume: 100 µL

Variant

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Product Details

Target

Ankyrin-R

Target Description

Ankyrin-1 or -Ankyrin-R is encoded by the gene ANK1. Ankyrin R is a scaffold protein that functions to link proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane cytoskeleton. In this manner, ankyrin family proteins play key roles in various processes including cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Ankyrin R is found expressed in erythrocytes, skeletal muscle and brain. Diseases associated with this gene include Spherocytosis.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N388A/10

Isotype

IgG2b

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

ANK1 ANK

Molecular Weight

200 kDa

Antigen

Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R (accession number P16157) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2491109

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with Ankyrin-B or Ankyrin-G

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin)

UniProt Details

UniProt (Human): P16157
UniProt (Immunogen Species): P16157

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Anti-Ankyrin-R Antibody (N388A/10)

Available Conjugates

Anti-Ankyrin-R Antibody
SKU: 75-380

Bulk Order Anti-Ankyrin-R Antibody

Product Details

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Anti-Ankyrin-R Antibody (N388A/10)

Available Conjugates

Anti-Ankyrin-R Antibody SKU: 75-380

Bulk Order Anti-Ankyrin-R Antibody

Product Details

Anti-Ankyrin-R Antibody
SKU: 75-380