Ankyrin-1 or -Ankyrin-R is encoded by the gene ANK1. Ankyrin R is a scaffold protein that functions to link proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane cytoskeleton. In this manner, ankyrin family proteins play key roles in various processes including cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Ankyrin R is found expressed in erythrocytes, skeletal muscle and brain. Diseases associated with this gene include Spherocytosis.
Purified by Protein A chromatography
ICC, IHC, WB
Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R (accession number P16157) produced recombinantly in E. Coli
Human, Mouse, Rat
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Does not cross-react with Ankyrin-B or Ankyrin-G
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.