Ankyrin-1 or -Ankyrin-R is encoded by the gene ANK1. Ankyrin R is a scaffold protein that functions to link proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane cytoskeleton. In this manner, ankyrin family proteins play key roles in various processes including cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Ankyrin R is found expressed in erythrocytes, skeletal muscle and brain. Diseases associated with this gene include Spherocytosis.
IHC, ICC, WB
Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R (also known as Ankyrin-1, Erythrocyte Ankyrin, ANK-1, ANK and rCG_43073, accession number P16157); Mouse: 90% identity (1678/1858 amino acids identical); Rat: 74% identity (1329/1788 amino acids identical); 50% identity with Ankyrin-B and Ankyrin-G
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not cross-react with Ankyrin-B or Ankyrin-G
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.