Noggin, Human, Purified Recombinant Protein

Name: Noggin, Human, Purified Recombinant Protein
Brand: Biosensis
SKU: PE-1245-10
Price: 447.0 USD
Availability: InStock

Noggin, purified human recombinant protein, suitable for cell culture.

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Applications

Cell Culture

Host Species

HEK293

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Data Sheet

SKU: PE-1245-10

Volume/Size: 10 µg

Variant

Price:

$447.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Noggin

Scientific Background

Noggin is a glycoprotein predominantly expressed by the dorsal mesoderm during embryogenesis and is secreted as a covalently linked homodimer. Noggin is essential for cartilage morphogenesis and joint formation. It is an inhibitor of bone morphogenic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Defects in Noggin are a cause of symphalangism proximal syndrome (SYM1), of multiple synostoses syndrome 1 (SYNS1), of the tarsal-carpal coalition syndrome (TCC), of stapes ankylosis with broad thumb and toes, and of brachydactyly type B2 (BDB2).

Format

Purified. The Noggin product consists of 5-25% carbohydrate by weight.

Applications

Cell Culture

Host Species

HEK293

Protein Sequence

A DNA sequence encoding human Noggin protein (containing the signal peptide sequence and the mature human noggin sequence) was expressed in modified human 293 cells.

Storage

Reconstitute with sterile-filtered phosphate-buffered saline to a concentration of 20 µg/mL. Lyophilized products should be stored at 2-8°C. Following reconstitution, short-term storage at 2-8°C is recommended and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.

Physical State

Lyophilized

Production Notes

>95% purity as determined by SDS-PAGE and visualized by silver stain.

Buffer

When reconstituted in 0.5 mL sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Nog

UniProt ID

Q13253

Shipping

25°C (ambient)

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Noggin, Human, Purified Recombinant Protein

SKU: PE-1245-10

Product Details

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