EGFR-Fc Chimera, Human, Purified Recombinant Protein

Name: EGFR-Fc Chimera, Human, Purified Recombinant Protein
Brand: Biosensis
SKU: PE-1240-25
Price: 307.0 USD
Availability: InStock

Epidermal growth factor receptor (EGFR)-Fc Chimera, purified human recombinant protein, suitable to block.

Applications

Block

Host Species

HEK293

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Data Sheet

SKU: PE-1240-25

Volume/Size: 25 µg

Variant

Price:

$307.00

Quantity:

Product Details

Target

Epidermal growth factor receptor (EGFR)

Scientific Background

Epidermal Growth Factor (EGF) Receptor binds to EGF and other members of the EGF family such as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. At least 4 isoforms are produced by alternative splicing (reference SWISSPROT). The EGF receptor is a single-pass type I membrane protein containing an extracellular receptor domain, a transmembrane region and an intracellular domain with tyrosine kinase function.

Format

Purified. The EGF receptor-Fc chimera consists of 5-30% carbohydrate by weight.

Applications

Block

Host Species

HEK293

Protein Sequence

A DNA sequence encoding the signal peptide and extracellular domain of human Epidermal Growth Factor Receptor (amino acids 1-525) was fused to the Fc region of human IgG1 (amino acids 90-330). The chimeric protein was expressed in modified human 293 cells.

Storage

It is recommended that 0.5 mL of sterile phosphate-buffered saline be added to the vial. Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 2-8°C is recommended, with longer-term storage in aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.

Physical State

Lyophilized

Production Notes

>95% purity, as determined by SDS-PAGE and visualized by Coomassie Brilliant Blue

Buffer

When reconstituted in 0.5 mL sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Receptor tyrosine-protein kinase erbB-1; EGFR; Urogastrone; Pro-epidermal growth factor; EGF R; c-erbB-1; ERBB1

UniProt ID

P00533

Shipping

25°C (ambient)

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EGFR-Fc Chimera, Human, Purified Recombinant Protein

SKU: PE-1240-25

Product Details

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