Anti-Pan-Neurofascin (Extracellular) Antibody (A12/18)


Primary Antibody
Human, Mouse, Non-Human Primate, Rat
A12/18
ICC, IHC, IP, WB
Mouse
Purified
Nfasc
155, 186 kDa

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Anti-Pan-Neurofascin (Extracellular) Antibody
SKU: 75-172

Volume: 100 µL
Price:
Sale price$345


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Product Specific References for Applications and Species

Immunocytochemistry: Human
PMID Dilution Publication
353146741:100Keren-Kaplan, T., et al. 2022. RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin. Nature Communications, 1506.
311000611:50 (supe)Guardia, C. M., et al. 2019. Reversible association with motor proteins (RAMP): A streptavidin-based method to manipulate organelle positioning. PLoS Biology, e3000279.
26671463not listedvan Beuningen, S., et al. 2015. TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays. Neuron, 1208-26.
252837191:50-1:100Notturno, F., et al. 2014. Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy.. Journal of Neuroimmunology, 207-12.
248597531:100Lukinavičius, G., et al. 2014. Fluorogenic probes for live-cell imaging of the cytoskeleton.. Nature Methods, 731-3.
Immunocytochemistry: Mouse
PMID Dilution Publication
359781881:500Eichel, K., et al. 2022. Endocytosis in the axon initial segment maintains neuronal polarity. Nature, 128-135.
313283331:100Dubessy, A. L., et al. 2019. Role of a Contactin multi‐molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS. Glia, 2248-63.
270986871:500Fréal, A., et al. 2016. Cooperative Interactions between 480 kDa Ankyrin-G and EB Proteins Assemble the Axon Initial Segment. Journal of Neuroscience, 4421-33.
269475591:200D'Este, E., et al. 2016. Subcortical cytoskeleton periodicity throughout the nervous system. Scientific Reports, 22741.
25950943not listedPapandréou, M. J., et al. 2015. CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.. Journal of Neurochemistry, 527-37.
Immunocytochemistry: Non-Human Primate
PMID Dilution Publication
311000611:50 (supe)Guardia, C. M., et al. 2019. Reversible association with motor proteins (RAMP): A streptavidin-based method to manipulate organelle positioning. PLoS Biology, e3000279.
22649224not listedYap, C. C., et al. 2012. Doublecortin (DCX) mediates endocytosis of neurofascin independently of microtubule binding.. Journal of Neuroscience, 7439-53.
Immunocytochemistry: Rat
PMID Dilution Publication
33571451not listedZahavi, E. E., et al. 2021. Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers. Developmental Cell, 494-508.e7.
32958558not listedCollura, K. M., et al. 2020. The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are uniquely present in DRG axons and control retrograde signaling via the Gp130/JAK/STAT3 pathway. Journal of Biological Chemistry, 15427-37.
325531551:1000De Pace, R., et al. 2020. Synaptic Vesicle Precursors and Lysosomes Are Transported by Different Mechanisms in the Axon of Mammalian Neurons. Cell Reports, 107775.
32239080not listedGerasimaitė, R., et al. 2020. Efflux pump insensitive rhodamine-jasplakinolide conjugates for G- and F-actin imaging in living cells. Organic & Biomolecular Chemistry, 2929-37.
318824531:100Gaub, B. M., et al. 2020. Neurons differentiate magnitude and location of mechanical stimuli. Proceedings of the National Academy of Sciences, 848-856.
31727776not listedTorii, T., et al. 2020. NuMA1 promotes axon initial segment assembly through inhibition of endocytosis. Journal of Cell Biology, e201907048.
31658245not listedRibeiro, L. F., et al. 2019. SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function. PLoS Biology, e3000466.
309674281:200Harterink, M., et al. 2019. TRIM46 Organizes Microtubule Fasciculation in the Axon Initial Segment. Journal of Neuroscience, 4864-73.
30772082not listedFarías, G. G., et al. 2019. Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity. Neuron, 184-201.e8.
30598502not listedHivert, B., et al. 2019. ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment. . Journal of Cell Science, jcs219774.
300166221ug/mlKarasmanis, E.P., et al. 2018. Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin. Developmental Cell, 204-218.
29395909not listedBerger, S.L., et al. 2018. Localized Myosin II Activity Regulates Assembly and Plasticity of the Axon Initial Segment. Neuron, 555-570.
28828584not listedGuo, Y., et al. 2017. Neurons with Multiple Axons Have Functional Axon Initial Segments. Neuroscience Bulletin, 641-52.
28559423not listedGanguly, A., et al. 2017. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. Journal of Cell Biology, 2059-74.
28533267not listedPinatel, D., et al. 2017. The Kv1-associated molecules TAG-1 and Caspr2 are selectively targeted to the axon initial segment in hippocampal neurons. Journal of Cell Science, 2209-2220.
28394337not listedHarterink, M., et al. 2017. DeActs: genetically encoded tools for perturbing the actin cytoskeleton in single cells. Nature Methods, 479-82.
27932952not listedDumitrescu, A. S., et al. 2016. Evaluating Tools for Live Imaging of Structural Plasticity at the Axon Initial Segment. Frontiers in Cellular Neuroscience, 268.
27697928not listedAlbrecht, D., et al. 2016. Nanoscopic compartmentalization of membrane protein motion at the axon initial segment.. The Journal of Biology, 37-46.
27559088not listedGuo, X., et al. 2016. Rab5 and its effector FHF contribute to neuronal polarity through dynein-dependent retrieval of somatodendritic proteins from the axon. Proceedings of the National Academy of Sciences, E5318-27.
27356871not listedSohn, P. D., et al. 2016. Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.. Molecular Neurodegeneration, 47.
272205541:400Sidenstein, S. C., et al. 2016. Multicolour Multilevel STED nanoscopy of Actin/Spectrin Organization at Synapses.. Scientific Reports, 26725.
268889351:100Benned-Jensen, T., et al. 2016. Live Imaging of Kv7.2/7.3 Cell Surface Dynamics at the Axon Initial Segment: High Steady-State Stability and Calpain-Dependent Excitotoxic Downregulation Revealed.. Journal of Neuroscience, 2261-6.
265538751:100Norkett, R., et al. 2016. DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites.. The Journal of Biological Chemistry, 613-29.
26526995not listedEvans, M. D., et al. 2015. Rapid Modulation of Axon Initial Segment Length Influences Repetitive Spike Firing.. Cell Report, 1233-45.
26216902not listedGanguly, A., et al. 2015. A dynamic formin-dependent deep F-actin network in axons.. The Journal of Biology, 401-417.
260193481:200Franssen, E. H., et al. 2015. Exclusion of integrins from CNS axons is regulated by Arf6 activation and the AIS.. Journal of Neuroscience, 8359-75.
25950943not listedPapandréou, M. J., et al. 2015. CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.. Journal of Neurochemistry, 527-37.
25561543not listedFreeman, S.A., et al. 2015. Acceleration of conduction velocity linked to clustering of nodal components precedes myelination. . Proceedings of the National Academy of Sciences, E321-E328.
24959118not listedMuir, J., et al. 2014. Plasticity of GABAA receptor diffusion dynamics at the axon initial segment.. Frontiers in Neuroscience, 151.
247115031:100Jones, S. L., et al. 2014. Axon initial segment cytoskeleton comprises a multiprotein submembranous coat containing sparse actin filaments.. The Journal of Biology, 67-81.
22649224not listedYap, C. C., et al. 2012. Doublecortin (DCX) mediates endocytosis of neurofascin independently of microtubule binding.. Journal of Neuroscience, 7439-53.
Immunohistochemistry: Human
PMID Dilution Publication
322891571:3000Bekku, Y., et al. 2020. Independent anterograde transport and retrograde cotransport of domain components of myelinated axons. Journal of Cell Biology, e201906071.
26671463not listedvan Beuningen, S., et al. 2015. TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays. Neuron, 1208-26.
Immunohistochemistry: Rat
PMID Dilution Publication
30772082not listedFarías, G. G., et al. 2019. Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity. Neuron, 184-201.e8.
Pulsed-pH Live Imaging: Rat
PMID Dilution Publication
359781881:250Eichel, K., et al. 2022. Endocytosis in the axon initial segment maintains neuronal polarity. Nature, 128-135.
Western Blot: Human
PMID Dilution Publication
319003871:500Hamdan, H., et al. 2020. Mapping axon initial segment structure and function by multiplexed proximity biotinylation. Nature Communications, 100.
25378584not listedJain, S., et al. 2015. Polarized sorting of the copper transporter ATP7B in neurons mediated by recognition of a dileucine signal by AP-1.. Molecular Biology of the Cell, 218-28.
22473675not listedDhaunchak, A.S., et al. 2012. Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis.. Annals of Neurology, 601-13.
20830807not listedDhaunchak, A.S., et al. 2010. A proteome map of axoglial specializations isolated and purified from human central nervous system.. Glia, 1949-60.
Western Blot: Mouse
PMID Dilution Publication
360851621:10,000Hatayama, M., et al. 2022. SLITRK1-Mediated Noradrenergic Projection Suppression in the Neonatal Prefrontal Cortex. Communications Biology, 935.
31910261not listedLee, M., et al. 2020. Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain. Journal of Cell Biology, e201903033.
270986871:500Fréal, A., et al. 2016. Cooperative Interactions between 480 kDa Ankyrin-G and EB Proteins Assemble the Axon Initial Segment. Journal of Neuroscience, 4421-33.
25950943not listedPapandréou, M. J., et al. 2015. CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.. Journal of Neurochemistry, 527-37.
Western Blot: Rat
PMID Dilution Publication
287857241:1000Kneynsberg, A., et al. 2017. Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats. eNeuro, ENEURO.0043-17.2017.
25950943not listedPapandréou, M. J., et al. 2015. CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.. Journal of Neurochemistry, 527-37.
Additional Publications: Unspecified
PMID Publication
27631998Farías, G. G., et al. 2016. Imaging the Polarized Sorting of Proteins from the Golgi Complex in Live Neurons. Methods in Molecular Biology, 13-30.
25732815D'Este, E., et al. 2015. STED nanoscopy reveals the ubiquity of subcortical cytoskeleton periodicity in living neurons.. Cell Report, 1246-51.
22632975Galiano, M.R., et al. 2012. A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly.. Cell, 1125-39.
19001126Hedstrom, K.L., et al. 2008. AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity.. The Journal of Biology, 635-40.

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