Anti-Neurturin (NTN) Antibody

Name: Anti-Neurturin (NTN) Antibody
Brand: Biosensis
SKU: R-1669-100
Price: 457.0 USD
Availability: InStock

Our Anti-Neurturin (NTN) rabbit polyclonal primary antibody detects human Neurturin (NTN), and is IgG. It is validated for use in WB.

Western-Blot detection of human NRTN expressed in CHO cells. Line 1. hNRTN-containing CHOEBNALT85 cell culture supernatant. Line 2. Negative control - CHOEBNALT85 cell culture supernatant. 5 µl of supernatant were loaded per line. Primary antibody dilution 1:5000 was used. Antibody recognizes protein dimeric, and monomeric variants.

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Species Reactivity

Human

Applications

Host Species

Rabbit

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Data Sheet

SKU: R-1669-100

Volume/Size: 100 µg

Variant

Price:

$457.00

Quantity:

Product Details

Target

Neurturin (NTN)

Scientific Background

Neurturin (NTN) is a member of the GDNF family of neurotrophic factors. This protein is a potent survival factor for several populations of central and peripheral neurons in mature and developing rodents. FUNCTION: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. SUBUNIT: Homodimer; disulfide-linked. SUBCELLULAR LOCATION: Secreted protein. DISEASE: Defects in NRTN are a cause of Hirschsprung disease (HSCR). In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.

Format

IgG

Clonality

Polyclonal

Isotype

IgG

Applications

Host Species

Rabbit

Immunogen

Recombinant human NRTN protein produced using CHO-based suspension cell line. Protein was purified from the cell culture supernatant.

Immunogen Species

Human

Species Reactivity

Human

Storage

Store at 2-8°C upon receipt. As product is (NH4)2SO4 (ammonium sulfate) precipitate, mix well by pipetting or vortexing prior to use.

Physical State

Liquid

Production Notes

Protein G purified IgG

Buffer

Concentrated ammonium sulfate in PBS pH 7.4.

Dilution Ranges

WB: 1:500-1:1000

Conjugate

Unconjugated

Specificity

Antibody does not show cross-reactivity to other GDNF-family proteins.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

UniProt ID

Q99748

Shipping

2-8°C (on cold packs)

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Anti-Neurturin (NTN) Antibody

SKU: R-1669-100

Product Details

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