Anti-Nav1.1 Na+ Channel Antibody (K74/71)


Primary Antibody
Human, Mouse, Non-Human Primate, Rat
K74/71
ELISA, ICC, IHC, IP, WB
Mouse
Purified
Scn1a
220 kDa

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Anti-Nav1.1 Na+ Channel Antibody
SKU: 75-023

Volume: 100 µL
Price:
Sale price$345


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Product Specific References for Applications and Species

ELISA: Mouse
PMID Dilution Publication
337327971:200Han, Z., et al. 2021. Relative Quantification of NaV1. 1 Protein in Mouse Brains Using a Meso Scale Discovery-Electrochemiluminescence (MSD-ECL) Method. . Bio-protocol, e3910-e3910.
328480941:200Han, Z., et al. 2020. Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome. . Science translational medicine, eaaz6100.
Immunocytochemistry: Mouse
PMID Dilution Publication
28931427not listedHu, L., et al. 2017. Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer's disease by regulating cilia function.. Alzheimers Research and Therapy, 76.
255615431:400Freeman, S.A., et al. 2015. Acceleration of conduction velocity linked to clustering of nodal components precedes myelination. . Proceedings of the National Academy of Sciences, E321-E328.
201338731:100Brackenbury, W.J., et al. 2010. Functional reciprocity between Na+ channel Nav1. 6 and β1 subunits in the coordinated regulation of excitability and neurite outgrowth. . Proceedings of the National Academy of Sciences, 2283-2288.
190132471:100-1:250O'Malley, H.A., et al. 2009. Loss of Na+ channel β2 subunits is neuroprotective in a mouse model of multiple sclerosis. . Molecular and Cellular Neuroscience, 143-155.
Immunocytochemistry: Rat
PMID Dilution Publication
255615431:400Freeman, S.A., et al. 2015. Acceleration of conduction velocity linked to clustering of nodal components precedes myelination. . Proceedings of the National Academy of Sciences, E321-E328.
21118538not listedPersson, A.K., et al. 2010. Sodium-calcium exchanger and multiple sodium channel isoforms in intra-epidermal nerve terminals. . Molecular Pain, 1744-8069.
Immunohistochemistry: Human
PMID Dilution Publication
241079391:100–1:1000Puthussery, T., et al. 2013. NaV1. 1 channels in axon initial segments of bipolar cells augment input to magnocellular visual pathways in the primate retina. . Journal of Neuroscience, 16045-16059.
201474551:100Black, J.A., et al. 2010. Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1. 5. . Brain, 835-846.
184428831:200Zhao, P., et al. 2008. Voltage-gated sodium channel expression in rat and human epidermal keratinocytes: evidence for a role in pain. . Pain, 90-105.
Immunohistochemistry: Mouse
PMID Dilution Publication
35354025not listedKaneko, K., et al. 2022. Developmentally regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome.. Cell reports, 110580.
352198551:200Studtmann C., et al. 2022. NaV1.1 haploinsufficiency impairs glutamatergic and GABAergic neuron function in the thalamus.. Neurobiology of disease, 105672.
339105991:100Haigh, J.L., et al. 2021. Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice.. Genome Medicine, 69.
319336261:500Alshammari, M.A., et al. 2019. Changes in the Fluorescence Tracking of NaV1.6 Protein Expression in a BTBR T+Itpr3tf/J Autistic Mouse Model.. Neural Plasticity, 4893103.
313544361:200Yang, J., et al. 2019. Biophysical properties of somatic and axonal voltage-gated sodium channels in midbrain dopaminergic neurons. . Frontiers in Cellular Neuroscience, 17.
312828641:500Goff, K.M., et al. 2019. Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome.. Elife, e46846.
312012321:200Hosoi, N., et al. 2019. Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments.. Journal of Neuroscience, 6339-6353.
30125271not listedNunes, D., et al. 2018. Axonal sodium channel NaV1. 2 drives granule cell dendritic GABA release and rapid odor discrimination. . PLoS biology, e2003816.
269090211:500Alshammari, M.A., et al. 2016. Improved methods for fluorescence microscopy detection of macromolecules at the axon initial segment. . Frontiers in cellular neuroscience, 5.
238918061:1000Xiao, M., et al. 2013. FGF14 localization and organization of the axon initial segment. . Molecular and Cellular Neuroscience, 393-403.
233118671:200Papale, L.A., et al. 2013. Altered sleep regulation in a mouse model of SCN1A‐derived genetic epilepsy with febrile seizures plus (GEFS+).. Epilepsia, 625-634.
216764991:300Wykes, R., et al. 2012. Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice. . Neurobiology of aging, 1609-1623.
219943811:4000Wu, C., et al. 2011. Action potential generation at an axon initial segment-like process in the axonless retinal AII amacrine cell. . Journal of Neuroscience, 14654-14659.
211909431:20Kim, D.Y., et al. 2011. Reduced sodium channel Nav1. 1 levels in BACE1-null mice. . Journal of Biological Chemistry, 8106-8116.
20628201not listedWimmer, V.C., et al. 2010. Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus. . The Journal of clinical investigation, 2661-2671.
20375142not listedWimmer, V.C., et al. 2010. Axon initial segment dysfunction in epilepsy. . The Journal of physiology, 1829-1840.
18621130not listedDuflocq, A., et al. 2008. Nav1. 1 is predominantly expressed in nodes of Ranvier and axon initial segments. . Molecular and Cellular Neuroscience, 180-192.
178840881:50Lopez-Santiago, L.F., et al. 2007. Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. . Journal of molecular and cellular cardiology, 636-647.
171220531:1000Burkhalter, A., et al. 2006. Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses.. Journal of Neuroscience, 12274-82.
Immunohistochemistry: Non-Human Primate
PMID Dilution Publication
241079391:100–1:1000Puthussery, T., et al. 2013. NaV1. 1 channels in axon initial segments of bipolar cells augment input to magnocellular visual pathways in the primate retina. . Journal of Neuroscience, 16045-16059.
Immunohistochemistry: Rat
PMID Dilution Publication
26888923not listedKim, K.X., et al. 2016. Maturation of NaV and KV channel topographies in the auditory nerve spike initiator before and after developmental onset of hearing function. . Journal of Neuroscience, 2111-2118.
252949861:200Tian, C., et al. 2014. Molecular identity of axonal sodium channels in human cortical pyramidal cells. . Frontiers in cellular neuroscience, 297.
240770571:5000Vega, A.V., et al. 2013. Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression. . Scientific Reports, 1-8.
217343021:200Lysakowski, A., et al. 2011. Molecular microdomains in a sensory terminal, the vestibular calyx ending.. Journal of Neuroscience, 10101-10114.
215692471:100Ahn, H.S., et al. 2011. Nav1. 7 is the predominant sodium channel in rodent olfactory sensory neurons. . Molecular pain, 1744-8069.
191181651:250Lorincz, A., et al. 2008. Cell-type-dependent molecular composition of the axon initial segment. . Journal of Neuroscience, 14329-14340.
187695611:500-1:1000Mojumder, D.K., et al. 2008. Subcellular compartmentalization of two calcium binding proteins, calretinin and calbindin-28 kDa, in ganglion and amacrine cells of the rat retina. . Molecular Vision, 1600.
184428831:200Zhao, P., et al. 2008. Voltage-gated sodium channel expression in rat and human epidermal keratinocytes: evidence for a role in pain. . Pain, 90-105.
Meso Scale Discovery: Mouse
PMID Dilution Publication
326471081:200Kian Huat Lim, et al. 2020. Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression.. Nature Communications, 3501.
Western Blot: Mouse
PMID Dilution Publication
352198551:1000Studtmann C., et al. 2022. NaV1.1 haploinsufficiency impairs glutamatergic and GABAergic neuron function in the thalamus.. Neurobiology of disease, 105672.
33732797not listedHan, Z., et al. 2021. Relative Quantification of NaV1. 1 Protein in Mouse Brains Using a Meso Scale Discovery-Electrochemiluminescence (MSD-ECL) Method. . Bio-protocol, e3910-e3910.
32848094not listedHan, Z., et al. 2020. Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome. . Science translational medicine, eaaz6100.
318308091:1000Niibori, Y., et al. 2020. Sexually divergent mortality and partial phenotypic rescue after gene therapy in a mouse model of dravet syndrome. . Human gene therapy, 339-351.
319336261:500Alshammari, M.A., et al. 2019. Changes in the Fluorescence Tracking of NaV1.6 Protein Expression in a BTBR T+Itpr3tf/J Autistic Mouse Model.. Neural Plasticity, 4893103.
313080961:1000Gomez, C.D., et al. 2019. Early life inflammation increases CA1 pyramidal neuron excitability in a sex and age dependent manner through a chloride homeostasis disruption. . Journal of Neuroscience, 7244-7259.
30125271not listedNunes, D., et al. 2018. Axonal sodium channel NaV1. 2 drives granule cell dendritic GABA release and rapid odor discrimination. . PLoS biology, e2003816.
299565861:500Dash, B., et al. 2018. Nonmuscle myosin II isoforms interact with sodium channel alpha subunits. . Molecular pain, 1744806918788638.
268896021:1000Bosch, M.K., et al. 2016. Proteomic analysis of native cerebellar iFGF14 complexes.. Channels , 297-312.
252033141:200Li, T., et al. 2014. Action potential initiation in neocortical inhibitory interneurons. . PLoS Biology, e1001944.
238918061:1000Xiao, M., et al. 2013. FGF14 localization and organization of the axon initial segment. . Molecular and Cellular Neuroscience, 393-403.
221314241:500Kaphzan, H., et al. 2011. Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome.. Journal of Neuroscience, 17637-17648.
190132471:100-1:250O'Malley, H.A., et al. 2009. Loss of Na+ channel β2 subunits is neuroprotective in a mouse model of multiple sclerosis. . Molecular and Cellular Neuroscience, 143-155.
18621130not listedDuflocq, A., et al. 2008. Nav1. 1 is predominantly expressed in nodes of Ranvier and axon initial segments. . Molecular and Cellular Neuroscience, 180-192.
Western Blot: Rat
PMID Dilution Publication
196926091:500von Reyn, C.R., et al. 2009. Calpain mediates proteolysis of the voltage-gated sodium channel α-subunit. . Journal of Neuroscience, 10350-10356.
19411284not listedTobin, A.A., et al. 2009. Loss of cerebrovascular Shaker-type K+ channels: a shared vasodilator defect of genetic and renal hypertensive rats. . American Journal of Physiology-Heart and Circulatory Physiology, H293-H303.
Additional Publications: Unspecified
PMID Publication
25421039Wimmer, V.C., et al. 2015. Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain. . Journal of Comparative Neurology, 814-830.
18601978Vega, A.V., et al. 2008. Reduced expression of Nav1. 6 sodium channels and compensation by Nav1. 2 channels in mice heterozygous for a null mutation in Scn8a. . Neuroscience letters, 69-73.
18079688Mojumder, D.K., et al. 2007. Voltage-gated sodium channel alpha-subunits Na (v) 1.1, Na (v) 1.2, and Na (v) 1.6 in the distal mammalian retina. . Molecular Vision, 2163-2182.
17111377Van Wart, A., et al. 2007. Polarized distribution of ion channels within microdomains of the axon initial segment. . Journal of Comparative Neurology, 339-352.

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