Anti-GluA1/GluR1 Glutamate Receptor Recombinant Chicken Chimeric mAb Biotin Conjugate (N355/1)

Name: Anti-GluA1/GluR1 Glutamate Receptor Recombinant Chicken Chimeric mAb Biotin Conjugate
Brand: Aves Labs
SKU: 78-327-BTN
Price: 562.0 USD
Availability: InStock

Our chicken GluA1/GluR1 glutamate receptor biotin conjugate recombinant antibody from Aves Labs is produced in-house from clone N355/1. It detects human, mouse, and rat GluA1/GluR1 glutamate receptor and is purified by affinity chromatography. Works in ELISA, IHC, ICC, WB.

Anti-GluA1/GluR1 Glutamate Receptor Recombinant Chicken Chimeric mAb Biotin Conjugate

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Species Reactivity

Human, Mouse, Rabbit, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

Trial Size

SKU: 78-327-BTN

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

GluA1/GluR1 glutamate receptor

Scientific Background

Glutamate receptor 1 or GluA1/GluR1 glutamate receptor is a member of the glutamate-gated ion channel family. GluR1 funcitons as an excitatory neurotransmitter at many synapses in the central nervous system and is widely expressed in brain. Mutations in the GluR1 gene are associated with cerebral cortical dysplasia, Status Epilepticus, and depression.

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

N355/1

Isotype

IgY

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Gene Name

Gria1 Glur1

Molecular Weight

100 kDa

Immunogen

Fusion Protein Amino acids 1-389 (extracellular N-terminus) of rat GluA1/GluR1 (accession number P19490) produced recombinantly in E. Coli.

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rabbit, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N355/1 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N355/1 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Dilution Ranges

IHC: 1:250-1:1000
ICC: 1:250-1:1000

Conjugate

Biotin

Specificity

Does not cross-react with GluR2

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

GLUR 1 antibody; Glutamate receptor 1; GLUR A antibody; GluR-1; AMPA 1 antibody; AMPA-selective glutamate receptor 1; AMPA selective glutamate receptor 1 antibody; GluR-A; AMPA-selective glutamate receptor 1 antibody; GluR-K1; GluA1 antibody; Glutamate receptor ionotropic; GLUH1 antibody; GluA1; GluR K1 antibody; GluR-1 antibody; GluR-A antibody; GluR-K1 antibody; GLUR1 antibody; GLURA antibody; GluRK1 antibody; Glutamate receptor 1 antibody; Glutamate receptor ionotropic AMPA 1 antibody; Glutamate receptor ionotropic antibody; Glutamate receptor; ionotropic; Gria1 antibody; GRIA1_HUMAN antibody; HBGR1 antibody; MGC133252 antibody; OTTHUMP00000160643 antibody; OTTHUMP00000165781 antibody; THUMP00000224241 antibody; OTTHUMP00000224242 antibody; OTTHUMP00000224243 antibody; AMPA 1

UniProt ID

P19490
UniProt Summary: Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG2 or CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate. Resensitization is blocked by CNIH2 through interaction with CACNG8 in the CACNG8-containing AMPA receptors complex. Calcium (Ca(2+)) permeability depends on subunits composition and, heteromeric channels containing edited GRIA2 subunit are calcium-impermeable. Also permeable to other divalents cations such as strontium(2+) and magnesium(2+) and monovalent cations such as potassium(1+) and lithium(1+).

NCBI Gene ID

50592

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Anti-GluA1/GluR1 Glutamate Receptor Recombinant Chicken Chimeric mAb Biotin Conjugate (N355/1)

SKU: 78-327-BTN

Product Details

Bulk Order Anti-GluA1/GluR1 Glutamate Receptor Recombinant Chicken Chimeric mAb Biotin Conjugate

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