Anti-GluN1/NR1 Glutamate Receptor Recombinant Chicken Chimeric mAb FL550 Conjugate (N308/48)

Name: Anti-GluN1/NR1 Glutamate Receptor Recombinant Chicken Chimeric mAb FL550 Conjugate
Brand: Aves Labs
SKU: 78-272-FL550
Price: 562.0 USD
Availability: InStock

Our chicken Anti-GluN1/NR1 glutamate receptor FL550 conjugate recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N308/48. It detects human, mouse, and rat GluN1/NR1 is purified by affinity chromatography. It works in IHC, ICC.

Anti-GluN1/NR1 Glutamate Receptor Recombinant Chicken Chimeric mAb FL550 Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

594

650

Carrier-Free

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Data Sheet

Trial Size

SKU: 78-272-FL550

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-2 business days

Product Details

Target

GluN1/NR1 glutamate receptor

Scientific Background

Glutamate receptor 1, NMDA 1, or GluN1/NR1 also known as subunit 1 of the N-methyl-D-aspartate (NMDA) receptor. It is a member of the glutamate receptor channel superfamily and is a heteromeric glutamate-gated calcium ion channel. GluN1 is essential for synaptic function in the brain. GluN1 is expressed throughout the brain in cerebellum, thalamus, olfactory bulb and cortex in the membrane at postsynaptic density. GluN1 plays a key role in synaptogenesis, synaptic plasticity, memory acquisition and learning. Mutations in the GluN1 gene are associated with intellectual disability and cortical visual impairment and movement disorders.

Format

Purified by affinity chromatography

Concentration

0.5 mg/mL

Clonality

Recombinant

Clone

N308/48

Isotype

IgY

Applications

ICC, IHC

Host Species

Chicken

Gene Name

Grin1 Nmdar1

Molecular Weight

105 kDa

Excitation / Emission

FL550 Ex: 550 nm, Em: 575 nm

Immunogen

Fusion protein amino acids 42-361 (extracellular N-terminus) of rat NR1 (accession number P35439) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N308/48 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N308/48 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Dilution Ranges

IHC: 1:500-1:1000
ICC: 1:250-1:500

Conjugate

550

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by Western blot on rat brain membrane fraction and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)

UniProt ID

P35439-2

Shipping

Shipped on ice packs

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Anti-GluN1/NR1 Glutamate Receptor Recombinant Chicken Chimeric mAb FL550 Conjugate (N308/48)

SKU: 78-272-FL550

Product Details

Bulk Order Anti-GluN1/NR1 Glutamate Receptor Recombinant Chicken Chimeric mAb FL550 Conjugate

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