Anti-SynDIG1/Tmem90b Antibody (L42/17)
Our Anti-SynDIG1/Tmem90b mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L42/17. It detects human, mouse, and rat SynDIG1/Tmem90b, and is purified by Protein A chromatography. It is great for use in ICC, WB.
SKU: 75-251
Product Details
SynDIG1/Tmem90b
Transmembrane Protein 90B or Synapse Differentiation Inducing 1 (SynDIG1/Tmem90b) is encoded by the gene SYNDIG1 and a member of the interferon-induced transmembrane family of proteins. (IFITM). SynDIG1 is thought to regulate AMPA receptors and be involved in postsynaptic development and maturation. SynDIG1 is expressed in the brain at excitatory synapses and postsynaptic cells. Diseases associated with this gene include Episodic Kinesigenic Dyskinesia and Visual Epilepsy.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
L42/17
IgG2a
ICC, WB
Mouse
Syndig1 Tmem90b
36 kDa
Fusion protein amino acids 1-183 (cytoplasmic N-terminus) of mouse SynDIG1 (accession number A2ANU3) produced recombinantly in E. Coli
Human, Mouse, Rat
AB_10999753
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Unconjugated
No cross-reactivity reported
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Shipped on ice packs
Synapse differentiation-inducing gene protein 1 (SynDIG1) (Dispanin subfamily C member 2) (DSPC2) (Transmembrane protein 90B)
UniProt (Human): Q9H7V2
UniProt (Immunogen Species): A2ANU3
UniProt (Immunogen Species): A2ANU3
- Kirk LM, Ti SW, Bishop HI, Orozco-Llamas M, Pham M, Trimmer JS, Díaz E. (2016), 'Distribution of the SynDIG4/proline-rich transmembrane protein 1 in rat brain..' J Comp Neurol.. 10.1002/cne.23945.
- Sumioka A, Brown TE, Kato AS, Bredt DS, Kauer JA, Tomita S. (2011), 'PDZ binding of TARPγ-8 controls synaptic transmission but not synaptic plasticity..' Nat Neurosci.. 10.1038/nn.2952.
- Kalashnikova E, Lorca RA, Kaur I, Barisone GA, Li B, Ishimaru T, Trimmer JS, Mohapatra DP, Díaz E. (2010), 'SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development..' Neuron.. 10.1016/j.neuron.2009.12.021.