Human Mouse Rat
Fusion protein amino acids 257-388 of mouse SynCAM1 (also known as synaptic cell adhesion molecule 1, immunoglobulin superfamily member 4, nectin-like protein 2 or NECL-2, tumor suppressor in lung cancer 1 or TSLC-1, spermatogenic immunoglobulin superfamily or SgIGSF, Igsf4 and Ra175, accession number Q8R5M8), recognizes 1.4b isoform only (epitope narrowed to GLTQLPNSAEELDSEDLS)
Rat: 96% identity (129/134 amino acids identical)
Human: 89% identity (118/132 amino acids identical)<50% identity with other SynCAM’s
No cross-reactivity with SynCAM2 or SynCAM3
Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)
Cadm1 Igsf4 Necl2 Ra175 Syncam SynCam1 Tslc1
TC Supernatant: AB_10671665
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecularweight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.
Citations and References
- Rollenhagen M, Kuckuck S, Ulm C, Hartmann M, Galuska SP, Geyer R, Geyer H, Mühlenhoff M.. (2012), 'Polysialylation of the synaptic cell adhesion molecule 1 (SynCAM 1) depends exclusively on the polysialyltransferase ST8SiaII in vivo. .' The Journal of Biological Chemistry. 10.1074/jbc.M112.375642. "