Human Mouse Rat
SynCAM1 cell adhesion molecule, Immunoglobulin superfamily member 4 (IgSF4), or Nectin-like protein 2 (NECL-2) is encoded by the gene CADM1 and is a member of the Immunoglobulin-like Cell Adhesion Molecules family. SynCam1 is a cell adhesion molecule involved in many cell processes including the mediation of cell-cell adhesion and assembly, neuronal migration axon growth and differentiation. SynCAM1 is expressed in many tissue types including, brain, lung, kidney, heart, spleen and liver. Diseases associated with this gene include Retroperitoneal Fibrosis and Neuromyelitis Optica Spectrum Disorder.
Fusion protein amino acids 257-388 of mouse SynCAM1 (also known as synaptic cell adhesion molecule 1, immunoglobulin superfamily member 4, nectin-like protein 2 or NECL-2, tumor suppressor in lung cancer 1 or TSLC-1, spermatogenic immunoglobulin superfamily or SgIGSF, Igsf4 and Ra175, accession number Q8R5M8), recognizes 1.4b isoform only (epitope narrowed to GLTQLPNSAEELDSEDLS); Rat: 96% identity (129/134 amino acids identical); Human: 89% identity (118/132 amino acids identical)Less than 50% identity with other SynCAM’s
No cross-reactivity with SynCAM2 or SynCAM3
Cadm1 Igsf4 Necl2 Ra175 Syncam SynCam1 Tslc1
TC Supernatant: AB_10671665
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.