Anti-Navbeta2 Na+ Channel Antibody (N395/68)

Name: Anti-Navbeta2 Na+ Channel Antibody
Brand: NeuroMab
SKU: 75-379
Price: 319.0 USD
Availability: InStock

3 Citations

Our Anti-Navbeta2 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N395/68. It is KO validated, detects mouse and rat Navbeta2 Na+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Immunoblot against crude membranes from adult rat brain (RBM) and wild-type (WT) and Navbeta2 knockout (KO) mouse brains probed with N395/68 (left) and N52A/42 (right) TC supe. Mouse brains courtesy of Lori Isom (University of Michigan).

Adult rat hippocampus immunohistochemistry.

Species Reactivity

Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

KO Validated

SKU: 75-379

Volume: 100 µL

Variant

Price:

$319

Quantity:

Product Details

Target

Navbeta2 Na+ channel

Target Description

Sodium channel subunit beta-2 or Navbeta2 Na+ channel is encoded by SCN2B. Voltage gated sodium channels are made up of an alpha (pore forming) subunit and 1 or 2 beta subunits. Navß2 is a transmembrane protein and acts as a regulatory subunit in excitable membranes and modulates the kinetics of channel. Nabß2 is expressed in many tissues, including the central and peripheral nervous system, heart, and skeletal muscle. Diseases associated with this gene include Familial Atrial Fibrillation

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N395/68

Isotype

IgG2b

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Scn2b Gm183

Molecular Weight

40 kDa

Antigen

Fusion protein amino acids 1-215 (full-length) of mouse Navbeta2 (accession number Q56A07) produced recombinantly in E. Coli

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2315896

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with Navbeta1, Navbeta3 or Navbeta4 (based on KO validation results)

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Sodium channel subunit beta-2

UniProt Details

UniProt (Human): O60939
UniProt (Immunogen Species): Q56A07

Browne L, Smith KE, Jagger DJ. (2017), 'Identification of Persistent and Resurgent Sodium Currents in Spiral Ganglion Neurons Cultured from the Mouse Cochlea..' eNeuro. 10.1523/ENEURO.0303-17.2017.
Ji X, Saha S, Gao G, Lasek AW, Homanics GE, Guildford M, Tapper AR, Martin GE. (2017), 'The Sodium Channel β4 Auxiliary Subunit Selectively Controls Long-Term Depression in Core Nucleus Accumbens Medium Spiny Neurons..' Frontiers in Neuroscience. 10.3389/fncel.2017.00017.
Buffington SA, Rasband MN. (2013), 'Na+ channel-dependent recruitment of Navβ4 to axon initial segments and nodes of Ranvier..' Journal of Neuroscience. 10.1523/JNEUROSCI.4051-12.2013.

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Anti-Navbeta2 Na+ Channel Antibody (N395/68)

SKU: 75-379

Product Details

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