ICC IHC WB
Fusion protein amino acids 1-215 (full-length) of mouse Navbeta2 (also known as Sodium channel subunit beta-2, Scn2b, UNQ326/PRO386 and Gm183, accession number Q56A07)
Rat: 97% identity (209/215 amino acids identical)
Human: 92% identity (198/215 amino acids identical)
30% identity with Navbeta1, Navbeta3 or Navbeta4
Does not cross-react with Navbeta1, Navbeta3 or Navbeta4 (based on KO validation results)
Sodium channel subunit beta-2
TC Supernatant: AB_2315895
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecularweight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
Citations and References
- Browne L, Smith KE, Jagger DJ.. (2017), 'Identification of Persistent and Resurgent Sodium Currents in Spiral Ganglion Neurons Cultured from the Mouse Cochlea. .' eNeuro. 10.1523/ENEURO.0303-17.2017. " "
- Ji X, Saha S, Gao G, Lasek AW, Homanics GE, Guildford M, Tapper AR, Martin GE.. (2017), 'The Sodium Channel β4 Auxiliary Subunit Selectively Controls Long-Term Depression in Core Nucleus Accumbens Medium Spiny Neurons. .' Frontiers in Neuroscience. 10.3389/fncel.2017.00017. " "
- Buffington SA, Rasband MN.. (2013), 'Na+ channel-dependent recruitment of Navβ4 to axon initial segments and nodes of Ranvier. .' Journal of Neuroscience. 10.1523/JNEUROSCI.4051-12.2013. "