Human Mouse Rat
MeCP2 (Methyl-CpG Binding Protein 2) is a chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair and is not influenced by sequences flanking the methyl-CpGs. MeCP2 has been shown to mediate transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A (Nan et al., 1998). Defects in MeCP2 are the cause of Rett syndrome (RTT) (Amir et al., 1999). RTT is an X-linked dominant disease; it is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
Synthetic peptide amino acids 157-169 (FTVTG[dimethyl-R]GSPSRRE) of human MECP2 (also known as Methyl-CpG-binding protein 2, accession number P51608)
Mouse: 100% identity (13/13 amino acids identical)
Rat: 100% identity (13/13 amino acids identical)
Reacts preferentially with dimethylated peptide than with unmethylated peptide
Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)
TC Supernatant: AB_11001717
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.