Human Mouse Rat
Leucine Rich Repeat Transmembrane Neuronal 4 is encoded by the gene LRRTM4. LRRTM4 is a member of the LRRTM family. LRRTM4 may play a role in the development and maintenance of the vertebrate nervous system. LRRTM4 exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation. LRRTM4 is expressed in neuronal tissues. No disorders were found to be associated with LRRTM4.
Synthetic peptide amino acids 470-484 (ARESERQMNSPLQEY, cytoplasmic C-terminus) of human LRRTM4 (also known as Leucine-rich repeat transmembrane neuronal protein 4, accession number Q86VH4)
Mouse: 100% identity (15/15 amino acids identical)
Rat: 100% identity (15/15 amino acids identical) 100% identity between Long and Short isoforms <50% identity with LRRTM1, LRRTM2 and LRRTM3
Reacts with both Long and Short isoforms
Leucine-rich repeat transmembrane neuronal protein 4
TC Supernatant: AB_10674105
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
Citations and References
- de Wit J1, O'Sullivan ML, Savas JN, Condomitti G, Caccese MC, Vennekens KM, Yates JR 3rd, Ghosh A.. (2013), 'Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development..' Neuron.. 10.1016/j.neuron.2013.06.049.