Kirre Like Nephrin Family Adhesion Molecule 3 is encoded by the gene KIRREL3. KIRREL3 is a member of the immunoglobulin superfamily, nephrin-like protein family. KIRREL3 is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. KIRREL3 is expressed in brain, bone marrow, and stromal cells. Diseases associated with KIRREL3 include Autosomal Dominant Non-Syndromic Intellectual Disability and Autosomal Dominant Non-Syndromic Intellectual Disability 4.
Fusion protein amino acids 46-524 (extracellular N-terminus) of rat Kirrel3 (also known as Kin of irregular chiasm-like protein 3, Kin of IRRE-like protein 3, Nephrin-like protein 2, NEPH2 and Kiaa1867, accession number Q09GS6)
Mouse: 97% identity (479/491 amino acids identical)
Human: 95% identity (470/491 amino acids identical)
100% identity between short and long isoforms
~50% identity with Kirrel1 and Kirrel2
Reacts with Kirrel3 short and long isoforms Does not cross-react with Kirrel1 and Kirrel2
Membrane protein KIRRE
TC Supernatant: AB_2315856
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
85-105 kDa (multiple isoforms)
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.