Lysine Demethylase 4A is encoded by the gene KDM4A. KDM4A is a member of the JHDM3 histone demethylase family. KDM4A is a nuclear protein that contains a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. KDM4A functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. KDM4A is expressed is several organs with the highest expression in the lungs. Diseases associated with KDM4A include Attention Deficit-Hyperactivity Disorder.
Fusion protein amino acids 568-674 of human JMJD2A (also known as JmjC domain-containing histone demethylation protein 3A, Jumonji domain-containing protein 2A, JHDM3A and KIAA0677, accession number O75164); Mouse: 94% identity (100/106 amino acids identical); Greater than 50% identity with JMJD2C
Does not cross-react with JMJD2C
KDM4A JHDM3A JMJD2 JMJD2A KIAA0677
TC Supernatant: AB_10671822
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.