Products: Primary Antibodies
PRODUCT OPTIONS
Brand | Catalog # | Option | Volume | Concentration | Price | |
---|---|---|---|---|---|---|
Brand![]() |
Catalog # 75-150 |
Option Purified |
Volume 100 µL |
Concentration 1 mg/mL |
Price $285.00 |
|
Brand![]() |
Catalog # 73-150 |
Option TC Supernatant |
Volume 5 mL |
Concentration Lot dependent |
Price $285.00 |
Product Details
Monoclonal
Mouse
IgG1
Human Mouse Rat
ICC IHC WB
HCN4 is a member of the hyperpolarization-activated cyclic nucleotide gated channel family, also known as pacemaker channels. This family has a role in rhythmic activity of the heart and firing neurons. HCN channels are made up of four subunits, HCN1-4 and can be formed in multiple combinations. HCN4 is found in the cell membrane as a multi pass membrane protein in the sino-atrial node of the heart. This protein is highly expressed in neurons in the thalamus and other brain regions and testis. Mutations in HCN4 have been found in several types of sinus bradycardia.
Fusion protein amino acids 1019-1108 (cytoplasmic Cterminus) of rat HCN4(also known as potassium/sodium hyperpolarization-activated cyclic nucleotidegated channel 4, brain cyclic nucleotide-gated channel 3 and BCNG-3, accession number Q9JKA7); Mouse: 100% identity (90/90 amino acids identical); Human: 100% identity (90/90 amino acids identical); Less than 50% identity with HCN1, HCN2 and HCN3
No cross-reactivity against other HCN’s
HCN4
HCN4
Purified: AB_2248534
TC Supernatant: AB_10673158
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
130 kDa
Quality Control
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.