Guanine nucleotide-binding protein G(s) subunit alpha isoforms short or Gs protein a subunit is encoded by the gene GNAS. Gsa is one of three subunits that make up a guanine nucleotide binding protein (Gprotein). The other proteins are a beta and a gamma subunit. G proteins are further divided into families depending on the type of a subunit included, G(S)alpha,G(Q)alpha,G(I)alpha,and G(12)alpha. Gsa functions as a transducer of numerous signaling pathways that are controlled by g protein coupled receptors (GPCRs) by coupling receptors to adenylyl cyclase and results in increased levels of the signaling molecule cAMP. Diseases associated with GNAS include Mccune-Albright Syndrome and Progressive Osseous Heteroplasia.
Fusion protein amino acids 1-380 (full-length, short form) of bovine Gs protein alpha subunit(also known as Guanine nucleotide-binding protein Gs subunit alpha isoforms short, GNAS, GNAS1, GSP, G-alpha-8 and Adenylate cyclase-stimulating G alpha protein, accession number P04896-2); Human: 99% identity (379/380 amino acids identical); Mouse: 99% identity (378/380 amino acids identical); Rat: 95% identity (377/394 amino acids identical); Significant identity with multiple Guanine nucleotide-binding proteins
Reacts with both Active and Inactive/QL forms
Gs protein, alpha subunit
TC Supernatant: AB_2315845
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.