Fusion protein amino acids 1-380 (full-length, short form) of bovine Gs protein alpha subunit(also known as Guanine nucleotide-binding protein Gs subunit alpha isoforms short, GNAS, GNAS1, GSP, G-alpha-8 and Adenylate cyclase-stimulating G alpha protein, accession number P04896-2)
Human: 99% identity (379/380 amino acids identical)
Mouse: 99% identity (378/380 amino acids identical)
Rat: 95% identity (377/394 amino acids identical)
Significant identity with multiple Guanine nucleotide-binding proteins
Reacts with both Active and Inactive/QL forms
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)
TC Supernatant: AB_2315845
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecularweight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
Citations and References
- Donati RJ,, Schappi J, Czysz AH, Jackson A, Rasenick MM.. (2015), 'Differential effects of antidepressants escitalopram versus lithium on Gs alpha membrane relocalization. .' BMC Neuroscience. 10.1186/s12868-015-0178-y. " "
- Sun Z, Runne C, Tang X, Lin F, Chen S.. (2012), 'The Gβ3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein. .' Cellular Signalling. 10.1016/j.cellsig.2012.08.011. " "
- Loo L, Shepherd AJ, Mickle AD, Lorca RA, Shutov LP, Usachev YM, Mohapatra DP.. (2012), 'The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical Gβγ-dependent modulation of TRPV1 channel. .' Journal of Neuroscience. 10.1523/JNEUROSCI.1330-12.2012. " "
- Soltysinska E, Thiele S, Olesen SP, Osadchii OE.. (2011), 'Chronic sympathetic activation promotes downregulation of β-adrenoceptor-mediated effects in the guinea pig heart independently of structural remodeling and systolic dysfunction. .' Pflügers Archiv: European Journal of Physiology. 10.1007/s00424-011-1005-7. "