Products: Primary Antibodies

Anti-Gamma-protocadherin-A3 Antibody (N144/17)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-177
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$275.00
Brand
NeuroMab Logo
Catalog #
73-177
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG1

Species Reactivity:

Mouse

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

ICC WB

Target Description:

Protocadherin gamma A3 is encoded by the gene Pcdhga3. Gamma-protocadherins belong to a superfamily of homophilic cell-adhesion proteins. These cell adhesion proteins are thought to be involved in establishing and function of cell-cell connections in brain. Gamma-Protocadherin-A3 is a type I transmembrane receptor and is a calcium-dependent cell-adhesion protein. Gamma-Protocadherin-A3 plays a role in the establishment and maintenance of specific neuronal connections in the brain. Gamma-Protocadherin-A3 is expressed in the central nervous system where it localizes to synapses. Diseases associated with this gene include Pineal Gland Cancer.

Immunogen:

Fusion protein amino acids 720-804 (variable cytoplasmic domain) of mouse Gamma-protocadherin-A3 (also known as PCDH-gamma-A3, accession number Q91XY5); Human: 80% identity (68/84 amino acids identical); Greater than 75% identity with other Gamma-protocadherin-A proteins

Cross Reactivity:

No cross-reactivity against other Gamma-protocadherin-A, -B or -C proteins

Protein Name(s):

Gamma-protocadherin-A3

Gene Name(s):

Pcdhga3

Antibody Registry ID:

Purified: AB_10671815
TC Supernatant: AB_10697874


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Knockout Validation:

This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).

Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Molecular Weight:

100 kDa


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.