Fusion protein amino acids 720-804 (variable cytoplasmic domain) of mouse Gamma-protocadherin-A3 (also known as PCDH-gamma-A3, accession number Q91XY5)
Human: 80% identity (68/84 amino acids identical)
>75% identity with other Gamma-protocadherin-A proteins
No cross-reactivity against other Gamma-protocadherin-A, -B or -C proteins
Protocadherin gamma A3 (Protocadherin gamma subfamily A, 3)
TC Supernatant: AB_10697874
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.
Citations and References
- Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E, Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR, Maniatis T.. (2012), 'Functional significance of isoform diversification in the protocadherin gamma gene cluster. .' Neuron. 10.1016/j.neuron.2012.06.039. " "
- Lobas MA, Helsper L, Vernon CG, Schreiner D, Zhang Y, Holtzman MJ, Thedens DR, Weiner JA.. (), 'Molecular heterogeneity in the choroid plexus epithelium: the 22-member γ-protocadherin family is differentially expressed, apically localized, and implicated in CSF regulation. .' Journal of Neurochemistry. 10.1111/j.1471-4159.2011.07587.x. "