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Products: Primary Antibodies

Anti-GABA-A-R-Epsilon Antibody (N413/67)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-398
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$275.00
Brand
NeuroMab Logo
Catalog #
73-398
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG2a

Species Reactivity:

Human Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

ICC IHC WB

Target Description:

Gamma-aminobutyric acid receptor subunit epsilon or GABA AR epsilon is encoded by the gene GABRE. GABA A receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR epsilon is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR epsilon is found expressed in many tissues including adult heart, placenta and adult brain. In brain, GABA AR epsilon is expressed at the cell junction, synapse, postsynaptic cell membrane and cytoplasmic vesicle membrane.

Immunogen:

Fusion protein amino acids 27-253 (extracellular N-terminus) of human GABA-A receptor Epsilon (also known as Gamma-aminobutyric acid receptor subunit epsilon and GABRE, accession number P78334)
Rat: 75% identity (171/228 amino acids identical)
Mouse: 76% identity (163/214 amino acids identical)
50% identity with other GABA-A receptors

Protein Name(s):

Gamma-aminobutyric acid receptor subunit epsilon (GABA(A) receptor subunit epsilon)

Gene Name(s):

GABRE

Antibody Registry ID:

Purified: AB_2493101
TC Supernatant: AB_2341105


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Immunohistochemistry:
This antibody shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Molecular Weight:

60 kDa


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.