Brevican core protein, Chondroitin sulfate proteoglycan 7 or Brain-enriched hyaluronan-binding protein is encoded by the gene BCAN and is a member of the lectican family of chondroitin sulfate proteoglycans. Brevican is involved in the development and formation of the brain extracellular matrix and may be involved in malignancy of brain tumor cells. Brevican is developmentally regulated and specifically expressed in the central nervous system. Diseases associated with this gene include Low-Grade Astrocytoma.
Fusion protein amino acids 219-655 of rat Brevican (also known as Brevican core protein, Brainenriched hyaluronan-binding protein, BEHAB, BCAN, Chondroitin sulfate proteoglycan 7 and CSPG7, accession number P55068)
Mouse: 92% identity (403/437 amino acids identical)
Human: 75% identity (350/464 amino acids identical)
40% identity with Aggrecan
Brevican core protein (Brain-enriched hyaluronan-binding protein) (BEHAB)
TC Supernatant: AB_11001257
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
140 kDa (and smaller due to proteolytic cleavage)
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.