ICC IHC WB
Cyclic AMP-dependent transcription factor ATF-4, Cyclic AMP-Responsive Element-Binding Protein 2, CREB2 or ATF4 is encoded by the gene ATF4 and is a member of the basic leucine-zipper (bZIP) superfamily. ATF4 is a transcriptional activator believed to be involved in many cell processes. ATF4 is widely expressed in tissues. In brain, ATF4 has been shown to localize in hippocampal neuron dendritic membranes. Diseases associated with ATF4 include Deafness, Mehmo Syndrome and T-Cell Leukemia.
Fusion protein amino acids 25-327 (nearly full-length, all but first 24 amino acids) of human ATF4 (also known as Activating transcription factor 4, Cyclic AMP-dependent transcription factor, Cyclic AMP-responsive element-binding protein 2, CREB-2, C/EBP-related ATF, C/ATF, Taxresponsive enhancer element-binding protein 67, DNA-binding protein TAXREB67 and TXREB, accession number P18848)
Rat: 86% identity (284/327 amino acids identical)
Mouse: 85% identity (280/328 amino acids identical)
<50% identity with ATF5
Does not cross-react with ATF5
Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (DNA-binding protein TAXREB67) (Tax-responsive enhancer element-binding protein 67) (TaxREB67)
ATF4 CREB2 TXREB
TC Supernatant: AB_2315806
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.