Anti-VIP Antibody (L108/92)

Name: Anti-VIP Antibody
Brand: NeuroMab
SKU: 75-447
Price: 337.0 USD
Availability: InStock

Our mouse VIP monoclonal antibody from NeuroMab is produced in-house from clone L108/92. It detects human, non-human primate, and rat VIP and is purified by Protein A chromatography. Works in IHC, ELISA.

Adult rat visual cortex (note interneurons) immunohistochemistry.

Adult rat stria terminalis immunohistochemistry.

Adult rat visual cortex (note interneurons) immunohistochemistry.

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Species Reactivity

Human, Non-Human Primate, Rat

Applications

ELISA, IHC

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-447

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

VIP

Scientific Background

Vasoactive Intestinal Peptide (VIP) or PHM27 is encoded by the gene VIP and belongs to the glucagon family. VIP is a secreted peptide hormone and binds to the VIP receptors VIP R1 and VIP R2. Signaling through the receptors, VIP is involved diverse processes including vasodilation, regulation of blood pressure, stimulates myocardial contractility and neurotransmission. VIP is produced in many tissues including gut, pancreas, heart and brain. Diseases associated with this gene include Vipoma and Vasomotor Rhinitis.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L108/92

Isotype

IgG2b

Applications

ELISA, IHC

Host Species

Mouse

Gene Name

VIP

Molecular Weight

19 kDa

Immunogen

Fusion protein amino acids 81-152 (mature protein) of human VIP (accession number P01282) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Non-Human Primate, Rat

Antibody Registry ID

AB_2651163

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

PHM27; VIP peptides [Cleaved into: Intestinal peptide PHV-42; prepro-VIP; Peptide histidine valine 42; Intestinal peptide PHM-27; Peptide histidine methioninamide 27; Vasoactive intestinal peptide; VIP; Vasoactive intestinal polypeptide

UniProt ID

P01282
UniProt Summary: [Vasoactive intestinal peptide]: VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles. Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

NCBI Gene ID

7432

Shipping

Shipped on ice packs

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Anti-VIP Antibody (L108/92)

SKU: 75-447

Product Details

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