Vasoactive Intestinal Peptide (VIP) or PHM27 is encoded by the gene VIP and belongs to the glucagon family. VIP is a secreted peptide hormone and binds to the VIP receptors VIP R1 and VIP R2. Signaling through the receptors, VIP is involved diverse processes including vasodilation, regulation of blood pressure, stimulates myocardial contractility and neurotransmission. VIP is produced in many tissues including gut, pancreas, heart and brain. Diseases associated with this gene include Vipoma and Vasomotor Rhinitis.
Fusion protein amino acids 81-152 (mature protein) of human VIP (also known as Vasoactive intestinal peptide and Vasoactive intestinal polypeptide, cleaved into Intestinal peptide PHI-42 / PHV-42 for Peptide histidine valine 42 and Intestinal peptide PHM-27 for Peptide histidine methioninamide 27 / Intestinal peptide PHI-27 for Peptide histidine isoleucinamide 27, accession number P01282); Rat: 92% identity (66/72 amino acids identical); Mouse: 90% identity (65/72 amino acids identical); 50% identity with PACAP
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