Anti-TRPML3/Mucolipin-3 Antibody (N268/19)

Name: Anti-TRPML3/Mucolipin-3 Antibody
Brand: NeuroMab
SKU: 75-283
Price: 319.0 USD
Availability: InStock

Our Anti-TRPML3/Mucolipin-3 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N268/19. It detects human, mouse, and rat TRPML3/Mucolipin-3, and is purified by Protein A chromatography. It is great for use in ICC, WB.

Tissue and transfected cell immunoblot: extracts of rat brain membranes (RBM) and of COS cells transiently transfected with HA-tagged mouse and human TRPML3 (mTRPML3 and hTRPML3) or untagged Kv2.1 plasmid and probed with N268/19 (left) and K89/34 (right) TC supe.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-283

Volume: 100 µL

Variant

Price:

$319

Quantity:

Product Details

Target

TRPML3/Mucolipin-3

Target Description

Mucolipin-3, Transient receptor potential cation channel, mucolipin subfamily, member 3 or TrpML3 is encoded by the gene MCOLN3. It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels and acts as an inwardly rectifying cation channel. TrpML3 is found in the cochlea, olfactory kidney, lung and hair cells and strial cells of the inner ear. The protein localizes to the plasma membrane, endosomes, and lysosomes of cells. Mutations in this gene in mice result in auditory hair cell death and deafness

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N268/19

Isotype

IgG2a

Applications

ICC, WB

Host Species

Mouse

Gene Name

MCOLN3

Molecular Weight

64 kDa

Antigen

Synthetic peptide amino acids 269-285 (CKDWHVSGSIQKNTHYM, extracellular N-terminus) of human TRPML3 (accession number Q8TDD5)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_11000726

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Mucolipin-3 (Transient receptor potential channel mucolipin 3) (TRPML3)

UniProt Details

UniProt (Human): Q8TDD5
UniProt (Immunogen Species): Q8TDD5

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Anti-TRPML3/Mucolipin-3 Antibody (N268/19)

SKU: 75-283

Product Details

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