Anti-TRPML3/Mucolipin-3 Antibody (N268/19)

Name: Anti-TRPML3/Mucolipin-3 Antibody
Brand: NeuroMab
SKU: 75-283
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet

filler

Clonality

Monoclonal

Applications

Host Species

Mouse

Gene Name

MCOLN3

Molecular Weight

64 kDa

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Tissue and transfected cell immunoblot: extracts of rat brain membranes (RBM) and of COS cells transiently transfected with HA-tagged mouse and human TRPML3 (mTRPML3 and hTRPML3) or untagged Kv2.1 plasmid and probed with N268/19 (left) and K89/34 (right) TC supe.

Product Details

Target

Mucolipin-3 (Transient receptor potential channel mucolipin 3) (TRPML3)

Target Description

Mucolipin-3, Transient receptor potential cation channel, mucolipin subfamily, member 3 or TrpML3 is encoded by the gene MCOLN3. It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels and acts as an inwardly rectifying cation channel. TrpML3 is found in the cochlea, olfactory kidney, lung and hair cells and strial cells of the inner ear. The protein localizes to the plasma membrane, endosomes, and lysosomes of cells. Mutations in this gene in mice result in auditory hair cell death and deafness

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N268/19

Isotype

IgG2a

Applications

Host Species

Mouse

Gene Name

MCOLN3

Molecular Weight

64 kDa

Antigen

Synthetic peptide amino acids 269-285 (CKDWHVSGSIQKNTHYM, extracellular N-terminus) of human TRPML3 (also known as Mucolipin-3 and MCOLN3, accession number Q8TDD5) Mouse: 100% identity (17/17 amino acids identical) Rat: 100% identity (17/17 amino acids identical) Less than 50% identity with TRPML2

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_11000726

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Mucolipin-3 (Transient receptor potential channel mucolipin 3) (TRPML3)

UniProt Details

UniProt (Human): Q8TDD5
UniProt (Immunogen Species): Q8TDD5

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Anti-TRPML3/Mucolipin-3 Antibody (N268/19)

Anti-TRPML3/Mucolipin-3 Antibody
SKU: 75-283

Product Details

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Anti-TRPML3/Mucolipin-3 Antibody (N268/19)

Anti-TRPML3/Mucolipin-3 Antibody SKU: 75-283

Product Details

Anti-TRPML3/Mucolipin-3 Antibody
SKU: 75-283