Anti-Thorase/Atad1 Antibody (N125/10)

Name: Anti-Thorase/Atad1 Antibody
Brand: NeuroMab
SKU: 75-157
Price: 337.0 USD
Availability: InStock

Our mouse Thorase/Atad1 monoclonal antibody from NeuroMab is produced in-house from clone N125/10. It detects human, mouse, and rat Thorase/Atad1 and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Adult rat hippocampus immunohistochemistry.

Immunoblots versus crude adult rat brain membranes (RBM) and brain extracts from Thorase WT and KO mice and probed with N125/10 (left) and N52A/42 (right) TC supe. Samples courtesy of Dr. Jianmin Zhang, Dr. Ted Dawson and Dr. Valina Dawson, Johns Hopkins School of Medicine.

Immunoblots on membranes prepared from whole mouse (MBM) and rat (RBM) brain, and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)], and cerebellum [HBM(Cb)].

Adult rat hippocampus immunohistochemistry.

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-157

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Thorase/Atad1

Scientific Background

ATPase Family AAA Domain-containing 1 is encoded by the gene ATAD1. ATAD1 plays a critical role in regulating the surface expression of AMPA receptors thereby regulating synaptic plasticity, learning, and memory. Diseases associated with ATAD1 include Hyperekplexia 4 and Hyperekplexia.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N125/10

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Atad1

Molecular Weight

40 kDa

Immunogen

Fusion protein amino acids 1-361 (full-length) of mouse Thorase (accession number Q9D5T0) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2290002

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.83

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

4921525H23Rik; ATPase family AAA domain-containing protein 1; Thorase; EC 3.6.1.3

UniProt ID

Q9D5T0
UniProt Summary: Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria. Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane. Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent.

NCBI Gene ID

67979

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Anti-Thorase/Atad1 Antibody (N125/10)

SKU: 75-157

Product Details

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