SynCAM1 cell adhesion molecule, Immunoglobulin superfamily member 4 (IgSF4), or Nectin-like protein 2 (NECL-2) is encoded by the gene CADM1 and is a member of the Immunoglobulin-like Cell Adhesion Molecules family. SynCam1 is a cell adhesion molecule involved in many cell processes including the mediation of cell-cell adhesion and assembly, neuronal migration axon growth and differentiation. SynCAM1 is expressed in many tissue types including, brain, lung, kidney, heart, spleen and liver. Diseases associated with this gene include Retroperitoneal Fibrosis and Neuromyelitis Optica Spectrum Disorder.
Cadm1 Igsf4 Necl2 Ra175 Syncam SynCam1 Tslc1
Fusion protein amino acids 257-388 of mouse SynCAM1 (also known as synaptic cell adhesion molecule 1, immunoglobulin superfamily member 4, nectin-like protein 2 or NECL-2, tumor suppressor in lung cancer 1 or TSLC-1, spermatogenic immunoglobulin superfamily or SgIGSF, Igsf4 and Ra175, accession number Q8R5M8), recognizes 1.4b isoform only (epitope narrowed to GLTQLPNSAEELDSEDLS); Rat: 96% identity (129/134 amino acids identical); Human: 89% identity (118/132 amino acids identical)Less than 50% identity with other SynCAM’s
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.