Immunoblot versus extracts of heart tissue from WT and SUR2 KO mice probed with N319A/14 TC supe. Data courtesy of William Coetzee and Margaret Rice, New York University SOM.
ATP-binding cassette sub-family C member 9 (Sulfonylurea receptor 2)
Sulfonylurea receptor 2A (SUR2A), or ATP binding cassette transporter subfamily C member 9 is encoded by the gene ABCC9 and is a member of the ABC transporter super family. Differential splicing of the ABCC9 gene produces 2 isoforms, SUR2A and SUR2B. SUR2A forms cardiac and smooth muscle-type KATP channels with KCNJ11(Kir6.2) and is involved in regulation and activation. Diseases associated with this gene include Cantu Syndrome and Dilated Cardiomyopathy 1O.
ICC, IHC, WB
Fusion protein amino acids 1505-1546 (SSIVDAGLVLVFSEGILVECDTGPNLLQHKNGLFSTLVMTNK, cytoplasmic C-terminus) of mouse SUR2A (also known as Sulfonylurea receptor 2A, ATP-binding cassette transporter sub-family C member 9A and Abcc9A, accession number P70170); Rat: 97% identity (41/42 amino acids identical); Human: 92% identity (39/42 amino acids identical); 100% identity with SUR2CLess than 50% identity with SUR2B
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