Anti-SK2 potassium channel Antibody (K78/29)

Name: Anti-SK2 potassium channel Antibody
Brand: NeuroMab
SKU: 75-403
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

K78/29

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

Kcnn2

Molecular Weight

50-80 kDa (and larger due to isoforms and dimerization/aggregation)

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Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with GFP-tagged SK1, SK3 or SK4 or untagged SK2 or Kv2.1 plasmid and probed with K78/29 (left) and N86/8 (right) TC supe.

Adult rat hippocampus immunohistochemistry.

Volume: 100 µL

Variant

Price:

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Product Details

Target

Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)

Target Description

Potassium calcium-activated channel subfamily N member 2 is encoded by the gene KCNN2. KCNN2 is a member of the potassium KCNN family, KCa2.2/KCNN2 subfamily. KCNN2 is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Activation of KCNN2 leads to membrane hyperpolarization. KCNN2 is expressed in the brain. Diseases associated with KCNN2 include Dyskeratosis Congenita, Autosomal Dominant 3 and Coronary Aneurysm.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K78/29

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnn2

Molecular Weight

50-80 kDa (and larger due to isoforms and dimerization/aggregation)

Antigen

Synthetic peptide amino acids 546-562 (ENYDKHVTYNAERSRSS, cytoplasmic C-terminus) of rat SK2 (also known as Small conductance calcium-activated potassium channel protein 2, SKCa2, KCa2.2 and Kcnn2, accession number P70604); Mouse: 94% identity (16/17 amino acids identical); Human: 94% identity (16/17 amino acids identical); 50% identity with SK3 and other SK channels

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2491099

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with other SK channels

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)

UniProt Details

UniProt (Human): Q9H2S1
UniProt (Immunogen Species): P70604

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Anti-SK2 potassium channel Antibody (K78/29)

Anti-SK2 potassium channel Antibody
SKU: 75-403

Bulk Order Anti-SK2 potassium channel Antibody

Product Details

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Anti-SK2 potassium channel Antibody (K78/29)

Anti-SK2 potassium channel Antibody SKU: 75-403

Bulk Order Anti-SK2 potassium channel Antibody

Product Details

Anti-SK2 potassium channel Antibody
SKU: 75-403