Anti-SK2 potassium channel Antibody (K78/29)

Name: Anti-SK2 potassium channel Antibody
Brand: NeuroMab
SKU: 75-403
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

K78/29

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

Kcnn2

Molecular Weight

50-80 kDa (and larger due to isoforms and dimerization/aggregation)

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Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with GFP-tagged SK1, SK3 or SK4 or untagged SK2 or Kv2.1 plasmid and probed with K78/29 (left) and N86/8 (right) TC supe.

Adult rat hippocampus immunohistochemistry.

Volume: 100 µL

Variant

Price:

$308

Quantity:

Bulk Order Anti-SK2 potassium channel Antibody

Product Details

Target

SK2 potassium channel

Target Description

Potassium calcium-activated channel subfamily N member 2 is encoded by the gene KCNN2. KCNN2 is a member of the potassium KCNN family, KCa2.2/KCNN2 subfamily. KCNN2 is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Activation of KCNN2 leads to membrane hyperpolarization. KCNN2 is expressed in the brain. Diseases associated with KCNN2 include Dyskeratosis Congenita, Autosomal Dominant 3 and Coronary Aneurysm.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K78/29

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnn2

Molecular Weight

50-80 kDa (and larger due to isoforms and dimerization/aggregation)

Antigen

Synthetic peptide amino acids 546-562 (ENYDKHVTYNAERSRSS, cytoplasmic C-terminus) of rat SK2 (accession number P70604)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2491099

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with other SK channels

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)

UniProt Details

UniProt (Human): Q9H2S1
UniProt (Immunogen Species): P70604

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Anti-SK2 potassium channel Antibody (K78/29)

Available Conjugates

Anti-SK2 potassium channel Antibody
SKU: 75-403

Bulk Order Anti-SK2 potassium channel Antibody

Product Details

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Anti-SK2 potassium channel Antibody (K78/29)

Available Conjugates

Anti-SK2 potassium channel Antibody SKU: 75-403

Bulk Order Anti-SK2 potassium channel Antibody

Product Details

Anti-SK2 potassium channel Antibody
SKU: 75-403