Adult rat hippocampus (top), thalamus (bottom left) and superior colliculus (bottom right) immunohistochemistry with antigen retrieval via pepsin pretreatment.
Disks large-associated protein 1 (SAPAP1) SAPAP-1
SAPAP1 (also known as disks large associated protein 1, DAP-1, or DLGAP1) is a member of the SAPAP or DLGAP family of proteins. SAPAP1 is part of the scaffold in neuronal cells of the brain and is a component of the postsynaptic complex. SAPAP1 acts as an adaptor protein that binds synaptic scaffold proteins, cytoskeletal proteins and signaling proteins including PSD-95 and SHANK. SAPAP1 is expressed in neurons of the cortex, hippocampus and in Purkinje cells in the cerebellum. Diseases associated with DLGAP1 include Retinitis Pigmentosa 55 and Obsessive-Compulsive Disorder
DLGAP1 DAP1 GKAP
110 kDa (varies due to post-translational modifications)
Fusion protein amino acids 772-992 (C-terminus) of rat SAPAP1 (also known as disks largeassociated protein 1, DAP-1, guanylate kinase-associated protein, GKAP, SAP90/PSD-95-associated/binding protein 1 and Dlgap1, accession number P97836); Mouse: 99% identity (200/201 amino acids identical) Human: 99% identity (199/201 amino acids identical) 55-65% identity with other SAPAPs
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.