Immunoblot versus adult rat brain membranes (RBM) and whole brain homogenates from S100A5-tauGFP (targeted deletion of S100A5 and replaced with coding region of tau fused to GFP) heterozygote (Het) and KO mice and probed with N176A/35 TC supe (left) and rabbit anti-S100A5 antibody (right). Samples courtesy of Tim McClintock, University of Kentucky.
Protein S100A5 is encoded by the gene S100A5 and a member of the S100 family of proteins. S100A5 is a calcium-binding cytosolic proteins and is also a member of the damage-associated molecular pattern molecules (DAMPs) family, a group of proteins that are released from the extracellular or intracellular space following tissue injury or cell death. S100A5 is localized in the cytoplasm and implicated in the regulation of a number of cellular processes such as cell cycle progression and extracellular signal transduction. S100A5 has been found in brain and kidney. Diseases associated with this gene include Astrocytoma.
Fusion protein amino acids 1-93 (full-length) of rat S100A (also known as S100 calcium-binding protein A5 and S-100D, accession number P63083); Mouse: 100% identity (93/93 amino acids identical); Human: 93% identity (87/93 amino acids identical); ~50% identity with S100A4 and S100A6
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not cross-react with S100A4 or S100A6 (based on KO validation results)
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from opening
Protein S100-A5 (Protein S-100D) (S100 calcium-binding protein A5)
UniProt (Human): P33763
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