Receptor expression-enhancing protein 1 (Spastic paraplegia 31 protein) Receptor expression-enhancing protein 2
The REEP protein family is made up of six REEP proteins 1-6. REEP1/2 are mitochondrial proteins that link ER tubules to the cytoskeleton and are involved in ER formation and remodeling. They may play a role in the cell surface expression of odorant receptors. Expression of the REEP1/REEP2 is found in neuronal and neuronal-like exocytotic tissues.
Fusion protein amino acids 111-254 (cytoplasmic C-terminus) of mouse REEP2 (also known as Receptor expression-enhancing protein 2, C5orf19, SGC32445 and LOC682105, accession number Q8VCD6)
Rat: 97% identity (140/144 amino acids identical); Human: 86% identity (125/144 amino acids identical); Less than 40% identity with REEP1 and REEP4 but Greater than 65% identity for first 46 amino acids (RDKSYETMMRVGKRGLNLAANAAVTAAAKGQGVLSEKLRSFSMQDL)
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