Nuclear Receptor Binding SET Domain Protein 3 is encoded by the gene NSD3. NSD3 is a member of the class V-like SAM-binding methyltransferase superfamily, histone/lysine methlytransferase family, SET2 subfamily. NSD3 methylates histone H3 at lysine residues 4 and 27, which represses gene expression. NSD3 is expressed in the brain, heart, skeletal muscle, liver, and lungs. Diseases associated with NSD3 include Wolf-Hirschhorn Syndrome and Nut Midline Carcinoma.
Purified by Protein A chromatography
ICC, IHC, WB
NSD3 WHSC1L1 DC28
Fusion protein amino acids 21-251 (N-terminus) of human NSD3 (accession number Q9BZ95) produced recombinantly in E. Coli
Human, Mouse, Rat
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
No cross-reactivity reported
Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from date of receipt
Shipped on ice packs
Histone-lysine N-methyltransferase NSD3 (EC 220.127.116.11) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)