Anti-NSD3 Antibody (N348/82)

Name: Anti-NSD3 Antibody
Brand: NeuroMab
SKU: 75-322
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

N348/82

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

NSD3 WHSC1L1 DC28

Molecular Weight

>160 kDa

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Transfected cell immunoblot: extracts of COS cells transiently transfected with HA-tagged NSD1, NSD2, NSD3 or untagged Kv2.1 plasmid and probed with N348/82 (left) and K89/34 (right) TC supe.

Adult rat hippocampus immunohistochemistry.

Volume: 100 µL

Variant

Price:

$308

Quantity:

Bulk Order Anti-NSD3 Antibody

Product Details

Target

Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.43) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)

Target Description

Nuclear Receptor Binding SET Domain Protein 3 is encoded by the gene NSD3. NSD3 is a member of the class V-like SAM-binding methyltransferase superfamily, histone/lysine methlytransferase family, SET2 subfamily. NSD3 methylates histone H3 at lysine residues 4 and 27, which represses gene expression. NSD3 is expressed in the brain, heart, skeletal muscle, liver, and lungs. Diseases associated with NSD3 include Wolf-Hirschhorn Syndrome and Nut Midline Carcinoma.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N348/82

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

NSD3 WHSC1L1 DC28

Molecular Weight

>160 kDa

Antigen

Fusion protein amino acids 21-251 (N-terminus) of human NSD3 (also known as Nuclear SET domain-containing protein 3, Histone-lysine N-methyltransferase, Wolf-Hirschhorn syndrome candidate 1-like protein 1, WHSC1-like protein 1, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, WHSC1L1, Protein whistle and DC28, accession number Q9BZ95); Mouse: 92% identity (214/231 amino acids identical); Rat: 90% identity (208/231 amino acids identical) 50% identity with NSD1 and NSD2

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2315902

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

UniProt Details

UniProt (Human): Q9BZ95
UniProt (Immunogen Species): Q9BZ95

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Anti-NSD3 Antibody (N348/82)

Anti-NSD3 Antibody
SKU: 75-322

Bulk Order Anti-NSD3 Antibody

Product Details

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Anti-NSD3 Antibody (N348/82)

Anti-NSD3 Antibody SKU: 75-322

Bulk Order Anti-NSD3 Antibody

Product Details

Anti-NSD3 Antibody
SKU: 75-322